Bibliography

Abecasis et al., 2002

Abecasis, G. R., Cherny, S. S., Cookson, W. O., and Cardon, L. R. (2002).
Merlin-rapid analysis of dense genetic maps using sparse gene flow trees.
Nat Genet, 30(1):97-101.

Abel and Muller-Myhsok, 1998

Abel, L. and Muller-Myhsok, B. (1998).
Robustness and power of the maximum-likelihood-binomial and maximum-likelihood-score methods, in multipoint linkage analysis of affected-sibship data.
Am J Hum Genet, 63(2):638-47.

Abrams et al., 2000

Abrams, J. R., Kelley, S. L., Hayes, E., Kikuchi, T., Brown, M. J., Kang, S., Lebwohl, M. G., Guzzo, C. A., Jegasothy, B. V., Linsley, P. S., and Krueger, J. G. (2000).
Blockade of t lymphocyte costimulation with cytotoxic t lymphocyte-associated antigen 4-immunoglobulin (ctla4ig) reverses the cellular pathology of psoriatic plaques, including the activation of keratinocytes, dendritic cells, and endothelial cells.
J Exp Med, 192(5):681-94.

Allen et al., 2003

Allen, M., Barker, J., A., B., A., B., N., C., and F., C. (2003).
The international psoriasis genetics study: assessing linkage to 14 candidate susceptibility loci in a cohort of 942 affected sib pairs.
Am J Hum Genet, 73(2):430-7.

Allen et al., 2001

Allen, M., Ishida-Yamamoto, A., McGrath, J., Davison, S., Iizuka, H., Simon, M., Guerrin, M., Hayday, A., Vaughan, R., Serre, G., Trembath, R., and Barker, J. (2001).
Corneodesmosin expression in psoriasis vulgaris differs from normal skin and other inflammatory skin disorders.
Lab Invest, 81(7):969-76.

Allen et al., 1999

Allen, M. H., Veal, C., Faassen, A., Powis, S. H., Vaughan, R. W., Trembath, R. C., and Barker, J. N. (1999).
A non-hla gene within the mhc in psoriasis.
Lancet, 353(9164):1589-90.

Ameen et al., 2005

Ameen, M., Allen, M. H., Fisher, S. A., Lewis, C. M., Cuthbert, A., Kondeatis, E., Vaughan, R. W., Murakami, H., Nakagawa, H., and Barker, J. N. (2005).
Corneodesmosin (cdsn) gene association with psoriasis vulgaris in caucasian but not in japanese populations.
Clin Exp Dermatol, 30(4):414-8.

Asensi et al., 2003

Asensi, V., Alvarez, V., Valle, E., Meana, A., Fierer, J., Coto, E., Carton, J. A., Maradona, J. A., Paz, J., Dieguez, M. A., de la Fuente, B., Moreno, A., Rubio, S., Tuya, M. J., Sarasua, J., Llames, S., and Arribas, J. M. (2003).
Il-1 alpha (-889) promoter polymorphism is a risk factor for osteomyelitis.
Am J Med Genet A, 119A(2):132-6.

Asumalahti et al., 2003a

Asumalahti, K., Ameen, M., Suomela, S., Hagforsen, E., Michaelsson, G., Evans, J., Munro, M., Veal, C., Allen, M., Leman, J., David Burden, A., Kirby, B., Connolly, M., Griffiths, C. E., Trembath, R. C., Kere, J., Saarialho-Kere, U., and Barker, J. N. (2003a).
Genetic analysis of psors1 distinguishes guttate psoriasis and palmoplantar pustulosis.
J Invest Dermatol, 120(4):627-32.

Asumalahti et al., 2000

Asumalahti, K., Laitinen, T., Itkonen-Vatjus, R., Lokki, M. L., Suomela, S., Snellman, E., Saarialho-Kere, U., and Kere, J. (2000).
A candidate gene for psoriasis near hla-c, hcr (pg8), is highly polymorphic with a disease-associated susceptibility allele.
Hum Mol Genet, 9(10):1533-42.

Asumalahti et al., 2003b

Asumalahti, K., Laitinen, T., Lahermo, P., Suomela, S., Itkonen-Vatjus, R., Jansen, C., Karvonen, J., Karvonen, S. L., Reunala, T., Snellman, E., Uurasmaa, T., Saarialho-Kere, U., and Kere, J. (2003b).
Psoriasis susceptibility locus on 18p revealed by genome scan in finnish families not associated with psors1.
J Invest Dermatol, 121(4):735-40.

Asumalahti et al., 2003c

Asumalahti, K., Saarialho-Kere, U., and Kere, J. (2003c).
[the pathogenesis of psoriasis-investigating the genetics of a multifactorial disease].
Duodecim, 119(16):1517-22.

Asumalahti et al., 2002

Asumalahti, K., Veal, C., Laitinen, T., Suomela, S., Allen, M., Elomaa, O., Moser, M., de Cid, R., Ripatti, S., Vorechovsky, I., Marcusson, J. A., Nakagawa, H., Lazaro, C., Estivill, X., Capon, F., Novelli, G., Saarialho-Kere, U., Barker, J., Trembath, R., and Kere, J. (2002).
Coding haplotype analysis supports hcr as the putative susceptibility gene for psoriasis at the mhc psors1 locus.
Hum Mol Genet, 11(5):589-97.

Balding et al., 2003

Balding, J., Kane, D., Livingstone, W., Mynett-Johnson, L., Bresnihan, B., Smith, O., and FitzGerald, O. (2003).
Cytokine gene polymorphisms: association with psoriatic arthritis susceptibility and severity.
Arthritis Rheum, 48(5):1408-13.

Balendran et al., 1999

Balendran, N., Clough, R. L., Arguello, J. R., Barber, R., Veal, C., Jones, A. B., Rosbotham, J. L., Little, A. M., Madrigal, A., Barker, J. N., Powis, S. H., and Trembath, R. C. (1999).
Characterization of the major susceptibility region for psoriasis at chromosome 6p21.3.
J Invest Dermatol, 113(3):322-8.

Barker, 1991

Barker, J. N. (1991).
The pathophysiology of psoriasis.
Lancet, 338(8761):227-30.

Barker et al., 2007

Barker, J. N., Palmer, C. N., Zhao, Y., Liao, H., Hull, P. R., Lee, S. P., Allen, M. H., Meggitt, S. J., Reynolds, N. J., Trembath, R. C., and McLean, W. H. (2007).
Null mutations in the filaggrin gene (flg) determine major susceptibility to early-onset atopic dermatitis that persists into adulthood.
J Invest Dermatol, 127(3):564-7.

Barton et al., 2005

Barton, A., Eyre, S., Bowes, J., Ho, P., John, S., and Worthington, J. (2005).
Investigation of the slc22a4 gene (associated with rheumatoid arthritis in a japanese population) in a united kingdom population of rheumatoid arthritis patients.
Arthritis Rheum, 52(3):752-8.

Begovich et al., 2004

Begovich, A. B., Carlton, V. E., Honigberg, L. A., Schrodi, S. J., Chokkalingam, A. P., Alexander, H. C., Ardlie, K. G., Huang, Q., Smith, A. M., Spoerke, J. M., Conn, M. T., Chang, M., Chang, S. Y., Saiki, R. K., Catanese, J. J., Leong, D. U., Garcia, V. E., McAllister, L. B., Jeffery, D. A., Lee, A. T., Batliwalla, F., Remmers, E., Criswell, L. A., Seldin, M. F., Kastner, D. L., Amos, C. I., Sninsky, J. J., and Gregersen, P. K. (2004).
A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (ptpn22) is associated with rheumatoid arthritis.
Am J Hum Genet, 75(2):330-7.

Bessis et al., 2005a

Bessis, D., Brun, P., Guilhou, J., Le Maître, M., Ortonne, J., and Samuelson, M. (2005a).
Le Psoriasis en médecine générale, chapter 3, pages 84-107.
Arnette.

Bessis et al., 2005b

Bessis, D., Brun, P., Guilhou, J., Le Maître, M., Ortonne, J., and Samuelson, M. (2005b).
Le Psoriasis en médecine générale, chapter 3, pages 109-113.
Arnette.

Bhalerao and Bowcock, 1998

Bhalerao, J. and Bowcock, A. M. (1998).
The genetics of psoriasis: a complex disorder of the skin and immune system.
Hum Mol Genet, 7(10):1537-45.

Bignell et al., 2000

Bignell, G. R., Warren, W., Seal, S., Takahashi, M., Rapley, E., Barfoot, R., Green, H., Brown, C., Biggs, P. J., Lakhani, S. R., Jones, C., Hansen, J., Blair, E., Hofmann, B., Siebert, R., Turner, G., Evans, D. G., Schrander-Stumpel, C., Beemer, F. A., van Den Ouweland, A., Halley, D., Delpech, B., Cleveland, M. G., Leigh, I., Leisti, J., and Rasmussen, S. (2000).
Identification of the familial cylindromatosis tumour-suppressor gene.
Nat Genet, 25(2):160-5.

Birnbaum et al., 2006

Birnbaum, R. Y., Zvulunov, A., Hallel-Halevy, D., Cagnano, E., Finer, G., Ofir, R., Geiger, D., Silberstein, E., Feferman, Y., and Birk, O. S. (2006).
Seborrhea-like dermatitis with psoriasiform elements caused by a mutation in znf750, encoding a putative c2h2 zinc finger protein.
Nat Genet, 38(7):749-51.

Blackwelder and Elston, 1985

Blackwelder, W. C. and Elston, R. C. (1985).
A comparison of sib-pair linkage tests for disease susceptibility loci.
Genet Epidemiol, 2(1):85-97.

Blakemore et al., 1994

Blakemore, A. I., Tarlow, J. K., Cork, M. J., Gordon, C., Emery, P., and Duff, G. W. (1994).
Interleukin-1 receptor antagonist gene polymorphism as a disease severity factor in systemic lupus erythematosus.
Arthritis Rheum, 37(9):1380-5.

Bois and Jollet, 2004

Bois, M. and Jollet, I. (2004).
Hla-cw, -dqb1 and -drb1 alleles in a population from west france.
Hum Immunol, 65:940-43.

Bonney, 1986

Bonney, G. E. (1986).
Regressive logistic models for familial disease and other binary traits.
Biometrics, 42(3):611-25.

Borgiani et al., 2002

Borgiani, P., Vallo, L., D'Apice, M. R., Giardina, E., Pucci, S., Capon, F., Nistico, S., Chimenti, S., Pallone, F., and Novelli, G. (2002).
Exclusion of card15/nod2 as a candidate susceptibility gene to psoriasis in the italian population.
Eur J Dermatol, 12(6):540-2.

Bottini et al., 2004

Bottini, N., Musumeci, L., Alonso, A., Rahmouni, S., Nika, K., Rostamkhani, M., MacMurray, J., Meloni, G. F., Lucarelli, P., Pellecchia, M., Eisenbarth, G. S., Comings, D., and Mustelin, T. (2004).
A functional variant of lymphoid tyrosine phosphatase is associated with type i diabetes.
Nat Genet, 36(4):337-8.

Bottini et al., 2006

Bottini, N., Vang, T., Cucca, F., and Mustelin, T. (2006).
Role of ptpn22 in type 1 diabetes and other autoimmune diseases.
Semin Immunol, 18(4):207-13.

Bowcock, 2005

Bowcock, A. M. (2005).
The genetics of psoriasis and autoimmunity.
Annu Rev Genomics Hum Genet, 6:93-122.

Bowcock and Cookson, 2004

Bowcock, A. M. and Cookson, W. O. (2004).
The genetics of psoriasis, psoriatic arthritis and atopic dermatitis.
Hum Mol Genet, 13 Spec No 1:R43-55.

Bowcock and Krueger, 2005

Bowcock, A. M. and Krueger, J. G. (2005).
Getting under the skin: the immunogenetics of psoriasis.
Nat Rev Immunol, 5(9):699-711.

Brookes, 1999

Brookes, A. J. (1999).
The essence of snps.
Gene, 234(2):177-86.

Brown, 2002

Brown, T. (2002).
Genomes 2, chapter 5, page 130.
Bios Scientific Publishers.

Butt et al., 2006

Butt, C., Peddle, L., Greenwood, C., Hamilton, S., Gladman, D., and Rahman, P. (2006).
Association of functional variants of ptpn22 and tp53 in psoriatic arthritis: a case-control study.
Arthritis Res Ther, 8(1):R27.

Butt et al., 2005

Butt, C., Sun, S., Greenwood, C., Gladman, D., and Rahman, P. (2005).
Lack of association of slc22a4, slc22a5, slc9a3r1 and runx1 variants in psoriatic arthritis.
Rheumatology (Oxford), 44(6):820-1.

Cambien et al., 1992

Cambien, F., Poirier, O., Lecerf, L., Evans, A., Cambou, J. P., Arveiler, D., Luc, G., Bard, J. M., Bara, L., Ricard, S., and et al. (1992).
Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction.
Nature, 359(6396):641-4.

Camp et al., 1990

Camp, R. D., Fincham, N. J., Ross, J. S., Bacon, K. B., and Gearing, A. J. (1990).
Leukocyte chemoattractant cytokines of the epidermis.
J Invest Dermatol, 95(6 Suppl):108S-110S.

Campion, 2001

Campion, D. (2001).
Dissection génétique des maladies à hérédité complexe.
Med Sci, 11(17):1139-48.

Candi et al., 2005

Candi, E., Schmidt, R., and Melino, G. (2005).
The cornified envelope: a model of cell death in the skin.
Nat Rev Mol Cell Biol, 6(4):328-40.

Capon et al., 2004a

Capon, F., Allen, M. H., Ameen, M., Burden, A. D., Tillman, D., Barker, J. N., and Trembath, R. C. (2004a).
A synonymous snp of the corneodesmosin gene leads to increased mrna stability and demonstrates association with psoriasis across diverse ethnic groups.
Hum Mol Genet, 13(20):2361-8.

Capon et al., 2007

Capon, F., Di Meglio, P., Szaub, J., Prescott, N. J., Dunster, C., Baumber, L., Timms, K., Gutin, A., Abkevic, V., Burden, A. D., Lanchbury, J., Barker, J. N., Trembath, R. C., and Nestle, F. O. (2007).
Sequence variants in the genes for the interleukin-23 receptor (il23r) and its ligand (il12b) confer protection against psoriasis.
Hum Genet, 122(2):201-206.

Capon et al., 2004b

Capon, F., Helms, C., Veal, C. D., Tillman, D., Burden, A. D., Barker, J. N., Bowcock, A. M., and Trembath, R. C. (2004b).
Genetic analysis of psors2 markers in a uk dataset supports the association between raptor snps and familial psoriasis.
J Med Genet, 41(6):459-60.

Capon et al., 1999a

Capon, F., Novelli, G., Semprini, S., Clementi, M., Nudo, M., Vultaggio, P., Mazzanti, C., Gobello, T., Botta, A., Fabrizi, G., and Dallapiccola, B. (1999a).
Searching for psoriasis susceptibility genes in italy: genome scan and evidence for a new locus on chromosome 1.
J Invest Dermatol, 112(1):32-5.

Capon et al., 2001

Capon, F., Semprini, S., Chimenti, S., Fabrizi, G., Zambruno, G., Murgia, S., Carcassi, C., Fazio, M., Mingarelli, R., Dallapiccola, B., and Novelli, G. (2001).
Fine mapping of the psors4 psoriasis susceptibility region on chromosome 1q21.
J Invest Dermatol, 116(5):728-30.

Capon et al., 1999b

Capon, F., Semprini, S., Dallapiccola, B., and Novelli, G. (1999b).
Evidence for interaction between psoriasis-susceptibility loci on chromosomes 6p21 and 1q21.
Am J Hum Genet, 65(6):1798-800.

Capon et al., 2003

Capon, F., Toal, I. K., Evans, J. C., Allen, M. H., Patel, S., Tillman, D., Burden, D., Barker, J. N., and Trembath, R. C. (2003).
Haplotype analysis of distantly related populations implicates corneodesmosin in psoriasis susceptibility.
J Med Genet, 40(6):447-52.

Cargill et al., 1999

Cargill, M., Altshuler, D., Ireland, J., Sklar, P., Ardlie, K., Patil, N., Shaw, N., Lane, C. R., Lim, E. P., Kalyanaraman, N., Nemesh, J., Ziaugra, L., Friedland, L., Rolfe, A., Warrington, J., Lipshutz, R., Daley, G. Q., and Lander, E. S. (1999).
Characterization of single-nucleotide polymorphisms in coding regions of human genes.
Nat Genet, 22(3):231-8.

Cargill et al., 2007

Cargill, M., Schrodi, S. J., Chang, M., Garcia, V. E., Brandon, R., Callis, K. P., Matsunami, N., Ardlie, K. G., Civello, D., Catanese, J. J., Leong, D. U., Panko, J. M., McAllister, L. B., Hansen, C. B., Papenfuss, J., Prescott, S. M., White, T. J., Leppert, M. F., Krueger, G. G., and Begovich, A. B. (2007).
A large-scale genetic association study confirms il12b and leads to the identification of il23r as psoriasis-risk genes.
Am J Hum Genet, 80(2):273-90.

Carlton et al., 2005

Carlton, V. E., Hu, X., Chokkalingam, A. P., Schrodi, S. J., Brandon, R., Alexander, H. C., Chang, M., Catanese, J. J., Leong, D. U., Ardlie, K. G., Kastner, D. L., Seldin, M. F., Criswell, L. A., Gregersen, P. K., Beasley, E., Thomson, G., Amos, C. I., and Begovich, A. B. (2005).
Ptpn22 genetic variation: evidence for multiple variants associated with rheumatoid arthritis.
Am J Hum Genet, 77(4):567-81.

Cassidy et al., 2005

Cassidy, A. J., van Steensel, M. A., Steijlen, P. M., van Geel, M., van der Velden, J., Morley, S. M., Terrinoni, A., Melino, G., Candi, E., and McLean, W. H. (2005).
A homozygous missense mutation in tgm5 abolishes epidermal transglutaminase 5 activity and causes acral peeling skin syndrome.
Am J Hum Genet, 77(6):909-17.

Cebrian et al., 2005

Cebrian, A., Lesueur, F., Martin, S., Leyland, J., Ahmed, S., Luccarini, C., Smith, P. L., Luben, R., Whittaker, J., Pharoah, P. D., Dunning, A. M., and Ponder, B. A. (2005).
Polymorphisms in the initiators of ret (rearranged during transfection) signaling pathway and susceptibility to sporadic medullary thyroid carcinoma.
J Clin Endocrinol Metab, 90(11):6268-74.

Chae et al., 2003

Chae, S. C., Yoon, K. H., and Chung, H. T. (2003).
Identification of novel polymorphisms in the adam33 gene.
J Hum Genet, 48(5):278-81.

Chamaillard et al., 2003

Chamaillard, M., Philpott, D., Girardin, S. E., Zouali, H., Lesage, S., Chareyre, F., Bui, T. H., Giovannini, M., Zaehringer, U., Penard-Lacronique, V., Sansonetti, P. J., Hugot, J. P., and Thomas, G. (2003).
Gene-environment interaction modulated by allelic heterogeneity in inflammatory diseases.
Proc Natl Acad Sci U S A, 100(6):3455-60.

Chang et al., 2008a

Chang, M., Li, Y., Yan, C., Callis-Duffin, K. P., Matsunami, N., Garcia, V. E., Cargill, M., Civello, D., Bui, N., Catanese, J. J., Leppert, M. F., Krueger, G. G., Begovich, A. B., and Schrodi, S. J. (2008a).
Variants in the 5q31 cytokine gene cluster are associated with psoriasis.
Genes Immun, 9(2):176-81.

Chang et al., 2008b

Chang, Y. C., Wu, W. M., Chen, C. H., Hu, C. F., and Hsu, L. A. (2008b).
Association between p478s polymorphism of the filaggrin gene and risk of psoriasis in a chinese population in taiwan.
Arch Dermatol Res, 300(3):133-7.

Chang et al., 2006

Chang, Y. T., Chou, C. T., Shiao, Y. M., Lin, M. W., Yu, C. W., Chen, C. C., Huang, C. H., Lee, D. D., Liu, H. N., Wang, W. J., and Tsai, S. F. (2006).
Psoriasis vulgaris in chinese individuals is associated with psors1c3 and cdsn genes.
Br J Dermatol, 155(4):663-9.

Chang et al., 2007

Chang, Y. T., Chou, C. T., Yu, C. W., Lin, M. W., Shiao, Y. M., Chen, C. C., Huang, C. H., Lee, D. D., Liu, H. N., Wang, W. J., and Tsai, S. F. (2007).
Cytokine gene polymorphisms in chinese patients with psoriasis.
Br J Dermatol, 156(5):899-905.

Chang et al., 2004

Chang, Y. T., Shiao, Y. M., Chin, P. J., Liu, Y. L., Chou, F. C., Wu, S., Lin, Y. F., Li, L. H., Lin, M. W., Liu, H. N., and Tsai, S. F. (2004).
Genetic polymorphisms of the hcr gene and a genomic segment in close proximity to hla-c are associated with patients with psoriasis in taiwan.
Br J Dermatol, 150(6):1104-11.

Chang et al., 2003

Chang, Y. T., Tsai, S. F., Lee, D. D., Shiao, Y. M., Huang, C. Y., Liu, H. N., Wang, W. J., and Wong, C. K. (2003).
A study of candidate genes for psoriasis near hla-c in chinese patients with psoriasis.
Br J Dermatol, 148(3):418-23.

Chen et al., 2006

Chen, X., Tan, Z., Yue, Q., Liu, H., Liu, Z., and Li, J. (2006).
The expression of interleukin-23 (p19/p40) and inteleukin-12 (p35/p40) in psoriasis skin.
J Huazhong Univ Sci Technolog Med Sci, 26(6):750-2.

Chia et al., 2001

Chia, N. V., Stuart, P., Nair, R. P., Henseler, T., Jenisch, S., Lim, H. W., Christophers, E., Voorhees, J. J., and Elder, J. T. (2001).
Variations in the hcr (pg8) gene are unlikely to be causal for familial psoriasis.
J Invest Dermatol, 116(5):823-4.

Christophers, 2001

Christophers, E. (2001).
Psoriasis-epidemiology and clinical spectrum.
Clin Exp Dermatol, 26(4):314-20.

Cloutier and Veillette, 1999

Cloutier, J. F. and Veillette, A. (1999).
Cooperative inhibition of t-cell antigen receptor signaling by a complex between a kinase and a phosphatase.
J Exp Med, 189(1):111-21.

Consortium, 2003

Consortium, T. I. H. (2003).
The international hapmap project.
Nature, 426(6968):789-96.

Consortium, 2005

Consortium, T. I. H. (2005).
A haplotype map of the human genome.
Nature, 437(7063):1299-320.

Cookson et al., 2001

Cookson, W. O., Ubhi, B., Lawrence, R., Abecasis, G. R., Walley, A. J., Cox, H. E., Coleman, R., Leaves, N. I., Trembath, R. C., Moffatt, M. F., and Harper, J. I. (2001).
Genetic linkage of childhood atopic dermatitis to psoriasis susceptibility loci.
Nat Genet, 27(4):372-3.

Cox et al., 1999

Cox, A., Camp, N. J., Cannings, C., di Giovine, F. S., Dale, M., Worthington, J., John, S., Ollier, W. E., Silman, A. J., and Duff, G. W. (1999).
Combined sib-tdt and tdt provide evidence for linkage of the interleukin-1 gene cluster to erosive rheumatoid arthritis.
Hum Mol Genet, 8(9):1707-13.

Criswell et al., 2005

Criswell, L. A., Pfeiffer, K. A., Lum, R. F., Gonzales, B., Novitzke, J., Kern, M., Moser, K. L., Begovich, A. B., Carlton, V. E., Li, W., Lee, A. T., Ortmann, W., Behrens, T. W., and Gregersen, P. K. (2005).
Analysis of families in the multiple autoimmune disease genetics consortium (madgc) collection: the ptpn22 620w allele associates with multiple autoimmune phenotypes.
Am J Hum Genet, 76(4):561-71.

de Bakker et al., 2005

de Bakker, P. I., Yelensky, R., Pe'er, I., Gabriel, S. B., Daly, M. J., and Altshuler, D. (2005).
Efficiency and power in genetic association studies.
Nat Genet, 37(11):1217-23.

Demenais et al., 1996

Demenais, F., Martinez, M., and Lathrop, M. (1996).
Méthodes statistiques pour identifier les gènes dans les maladies multifactorielles.
Ann Instit Pasteur, 7(1):3-12.

Derrickson and Tortora, 2007

Derrickson, D. and Tortora, G. (2007).
Principes d'anatomie et de physiologie, chapter 5, pages 155-60.
de boeck.

Dib et al., 1996

Dib, C., Faure, S., Fizames, C., Samson, D., Drouot, N., Vignal, A., Millasseau, P., Marc, S., Hazan, J., Seboun, E., Lathrop, M., Gyapay, G., Morissette, J., and Weissenbach, J. (1996).
A comprehensive genetic map of the human genome based on 5,264 microsatellites.
Nature, 380(6570):152-4.

Diehl et al., 1999

Diehl, S. R., Wang, Y., Brooks, C. N., Burmeister, J. A., Califano, J. V., Wang, S., and Schenkein, H. A. (1999).
Linkage disequilibrium of interleukin-1 genetic polymorphisms with early-onset periodontitis.
J Periodontol, 70(4):418-30.

Dubois and Gebuhrer, 2004

Dubois, V. and Gebuhrer, L. (2004).
Hla-a, -b, -cw, -dpb1, -dqb1 and -drb1 alleles and kir gene frequencies in a population from south east france.
Hum Immunol, 65:937-39.

Duffy et al., 1993

Duffy, D. L., Spelman, L. S., and Martin, N. G. (1993).
Psoriasis in australian twins.
J Am Acad Dermatol, 29(3):428-34.

Duvic, 1990

Duvic, M. (1990).
Immunology of aids related to psoriasis.
J Invest Dermatol, 95(5 Suppl):38S-40S.

Elder, 2006

Elder, J. T. (2006).
Psors1: linking genetics and immunology.
J Invest Dermatol, 126(6):1205-6.

Elder et al., 1994

Elder, J. T., Nair, R. P., Guo, S. W., Henseler, T., Christophers, E., and Voorhees, J. J. (1994).
The genetics of psoriasis.
Arch Dermatol, 130(2):216-24.

Elomaa et al., 2004

Elomaa, O., Majuri, I., Suomela, S., Asumalahti, K., Jiao, H., Mirzaei, Z., Rozell, B., Dahlman-Wright, K., Pispa, J., Kere, J., and Saarialho-Kere, U. (2004).
Transgenic mouse models support hcr as an effector gene in the psors1 locus.
Hum Mol Genet, 13(15):1551-61.

Enerback et al., 1997

Enerback, C., Martinsson, T., Inerot, A., Wahlstrom, J., Enlund, F., Yhr, M., and Swanbeck, G. (1997).
Evidence that hla-cw6 determines early onset of psoriasis, obtained using sequence-specific primers (pcr-ssp).
Acta Derm Venereol, 77(4):273-6.

Enerback et al., 2000

Enerback, C., Nilsson, S., Enlund, F., Inerot, A., Samuelsson, L., Wahlstrom, J., Swanbeck, G., and Martinsson, T. (2000).
Stronger association with hla-cw6 than with corneodesmosin (s-gene) polymorphisms in swedish psoriasis patients.
Arch Dermatol Res, 292(11):525-30.

Enlund et al., 1999a

Enlund, F., Samuelsson, L., Enerback, C., Inerot, A., Wahlstrom, J., Yhr, M., Torinsson, A., Martinsson, T., and Swanbeck, G. (1999a).
Analysis of three suggested psoriasis susceptibility loci in a large swedish set of families: confirmation of linkage to chromosome 6p (hla region), and to 17q, but not to 4q.
Hum Hered, 49(1):2-8.

Enlund et al., 1999b

Enlund, F., Samuelsson, L., Enerback, C., Inerot, A., Wahlstrom, J., Yhr, M., Torinsson, A., Riley, J., Swanbeck, G., and Martinsson, T. (1999b).
Psoriasis susceptibility locus in chromosome region 3q21 identified in patients from southwest sweden.
Eur J Hum Genet, 7(7):783-90.

Fan et al., 2008

Fan, X., Yang, S., Huang, W., Wang, Z. M., Sun, L. D., Liang, Y. H., Gao, M., Ren, Y. Q., Zhang, K. Y., Du, W. H., Shen, Y. J., Liu, J. J., and Zhang, X. J. (2008).
Fine mapping of the psoriasis susceptibility locus psors1 supports hla-c as the susceptibility gene in the han chinese population.
PLoS Genet, 4(3):e1000038.

Feinberg and Tycko, 2004

Feinberg, A. P. and Tycko, B. (2004).
The history of cancer epigenetics.
Nat Rev Cancer, 4(2):143-53.

Feingold, 2005

Feingold, J. (2005).
Maladies multifactorielles: un cauchemar pour le généticien.
Med Sci, 11(21):927-33.

Feingold et al., 1998

Feingold, J., Fellous, M., and Solignac, M. (1998).
Principes de génétique humaine, chapter 12, pages 305-319.
Hermann.

Friberg et al., 2006

Friberg, C., Bjorck, K., Nilsson, S., Inerot, A., Wahlstrom, J., and Samuelsson, L. (2006).
Analysis of chromosome 5q31-32 and psoriasis: confirmation of a susceptibility locus but no association with snps within slc22a4 and slc22a5.
J Invest Dermatol, 126(5):998-1002.

Giardina et al., 2004

Giardina, E., Novelli, G., Costanzo, A., Nistico, S., Bulli, C., Sinibaldi, C., Sorgi, M. L., Chimenti, S., Pallone, F., Taccari, E., and Borgiani, P. (2004).
Psoriatic arthritis and card15 gene polymorphisms: no evidence for association in the italian population.
J Invest Dermatol, 122(5):1106-7.

Giardina et al., 2006

Giardina, E., Predazzi, I., Sinibaldi, C., Peconi, C., Amerio, P., Costanzo, A., Paradisi, A., Capizzi, R., Paradisi, M., Chimenti, S., Taccari, E., and Novelli, G. (2006).
Psors2 markers are not associated with psoriatic arthritis in the italian population.
Hum Hered, 61(2):120-2.

Gjorloff-Wingren et al., 1999

Gjorloff-Wingren, A., Saxena, M., Williams, S., Hammi, D., and Mustelin, T. (1999).
Characterization of tcr-induced receptor-proximal signaling events negatively regulated by the protein tyrosine phosphatase pep.
Eur J Immunol, 29(12):3845-54.

Gladman, 1994

Gladman, D. D. (1994).
Natural history of psoriatic arthritis.
Baillieres Clin Rheumatol, 8(2):379-94.

Gottlieb et al., 1991

Gottlieb, A. B., Krueger, J. G., Khandke, L., Grossman, R. M., Krane, J., and Carter, D. M. (1991).
Role of t cell activation in the pathogenesis of psoriasis.
Ann N Y Acad Sci, 636:377-9.

Gottlieb et al., 1995

Gottlieb, S. L., Heftler, N. S., Gilleaudeau, P., Johnson, R., Vallat, V. P., Wolfe, J., Gottlieb, A. B., and Krueger, J. G. (1995).
Short-contact anthralin treatment augments therapeutic efficacy of cyclosporine in psoriasis: a clinical and pathologic study.
J Am Acad Dermatol, 33(4):637-45.

Griffiths and Barker, 2007

Griffiths, C. E. and Barker, J. N. (2007).
Pathogenesis and clinical features of psoriasis.
Lancet, 370(9583):263-71.

Groves et al., 1995

Groves, R. W., Mizutani, H., Kieffer, J. D., and Kupper, T. S. (1995).
Inflammatory skin disease in transgenic mice that express high levels of interleukin 1 alpha in basal epidermis.
Proc Natl Acad Sci U S A, 92(25):11874-8.

Groves et al., 1996

Groves, R. W., Rauschmayr, T., Nakamura, K., Sarkar, S., Williams, I. R., and Kupper, T. S. (1996).
Inflammatory and hyperproliferative skin disease in mice that express elevated levels of the il-1 receptor (type i) on epidermal keratinocytes. evidence that il-1-inducible secondary cytokines produced by keratinocytes in vivo can cause skin disease.
J Clin Invest, 98(2):336-44.

Gudbjartsson et al., 2000

Gudbjartsson, D. F., Jonasson, K., Frigge, M. L., and Kong, A. (2000).
Allegro, a new computer program for multipoint linkage analysis.
Nat Genet, 25(1):12-3.

Gudjonsson et al., 2007

Gudjonsson, J. E., Johnston, A., Dyson, M., Valdimarsson, H., and Elder, J. T. (2007).
Mouse models of psoriasis.
J Invest Dermatol, 127(6):1292-308.

Gudjonsson et al., 2003

Gudjonsson, J. E., Karason, A., Antonsdottir, A., Runarsdottir, E. H., Hauksson, V. B., Upmanyu, R., Gulcher, J., Stefansson, K., and Valdimarsson, H. (2003).
Psoriasis patients who are homozygous for the hla-cw*0602 allele have a 2.5-fold increased risk of developing psoriasis compared with cw6 heterozygotes.
Br J Dermatol, 148(2):233-5.

Gudjonsson et al., 2002

Gudjonsson, J. E., Karason, A., Antonsdottir, A. A., Runarsdottir, E. H., Gulcher, J. R., Stefansson, K., and Valdimarsson, H. (2002).
Hla-cw6-positive and hla-cw6-negative patients with psoriasis vulgaris have distinct clinical features.
J Invest Dermatol, 118(2):362-5.

Guerrin et al., 1998

Guerrin, M., Simon, M., Montezin, M., Haftek, M., Vincent, C., and Serre, G. (1998).
Expression cloning of human corneodesmosin proves its identity with the product of the s gene and allows improved characterization of its processing during keratinocyte differentiation.
J Biol Chem, 273(35):22640-7.

Guillaudeux et al., 1998

Guillaudeux, T., Janer, M., Wong, G. K., Spies, T., and Geraghty, D. E. (1998).
The complete genomic sequence of 424,015 bp at the centromeric end of the hla class i region: gene content and polymorphism.
Proc Natl Acad Sci U S A, 95(16):9494-9.

Haines and Pericak-Vance, 2006

Haines, J. and Pericak-Vance, M. (2006).
Genetic analysis of complex disease, chapter 15, page 437.
Wiley-liss.

Hall et al., 1990

Hall, J. M., Lee, M. K., Newman, B., Morrow, J. E., Anderson, L. A., Huey, B., and King, M. C. (1990).
Linkage of early-onset familial breast cancer to chromosome 17q21.
Science, 250(4988):1684-9.

Hasegawa et al., 2004

Hasegawa, K., Martin, F., Huang, G., Tumas, D., Diehl, L., and Chan, A. C. (2004).
Pest domain-enriched tyrosine phosphatase (pep) regulation of effector/memory t cells.
Science, 303(5658):685-9.

Helms et al., 2003

Helms, C., Cao, L., Krueger, J. G., Wijsman, E. M., Chamian, F., Gordon, D., Heffernan, M., Daw, J. A., Robarge, J., Ott, J., Kwok, P. Y., Menter, A., and Bowcock, A. M. (2003).
A putative runx1 binding site variant between slc9a3r1 and nat9 is associated with susceptibility to psoriasis.
Nat Genet, 35(4):349-56.

Helms et al., 2005

Helms, C., Saccone, N. L., Cao, L., Daw, J. A., Cao, K., Hsu, T. M., Taillon-Miller, P., Duan, S., Gordon, D., Pierce, B., Ott, J., Rice, J., Fernandez-Vina, M. A., Kwok, P. Y., Menter, A., and Bowcock, A. M. (2005).
Localization of psors1 to a haplotype block harboring hla-c and distinct from corneodesmosin and hcr.
Hum Genet, 118(3-4):466-76.

Henseler and Christophers, 1985

Henseler, T. and Christophers, E. (1985).
Psoriasis of early and late onset: characterization of two types of psoriasis vulgaris.
J Am Acad Dermatol, 13(3):450-6.

Hensen et al., 2003

Hensen, P., Windemuth, C., Huffmeier, U., Ruschendorf, F., Stadelmann, A., Hoppe, V., Fenneker, D., Stander, M., Schmitt-Egenolf, M., Wienker, T. F., Traupe, H., and Reis, A. (2003).
Association scan of the novel psoriasis susceptibility region on chromosome 19: evidence for both susceptible and protective loci.
Exp Dermatol, 12(4):490-6.

Hewett et al., 2002

Hewett, D., Samuelsson, L., Polding, J., Enlund, F., Smart, D., Cantone, K., See, C. G., Chadha, S., Inerot, A., Enerback, C., Montgomery, D., Christodolou, C., Robinson, P., Matthews, P., Plumpton, M., Wahlstrom, J., Swanbeck, G., Martinsson, T., Roses, A., Riley, J., and Purvis, I. (2002).
Identification of a psoriasis susceptibility candidate gene by linkage disequilibrium mapping with a localized single nucleotide polymorphism map.
Genomics, 79(3):305-14.

Hinds et al., 2005

Hinds, D. A., Stuve, L. L., Nilsen, G. B., Halperin, E., Eskin, E., Ballinger, D. G., Frazer, K. A., and Cox, D. R. (2005).
Whole-genome patterns of common dna variation in three human populations.
Science, 307(5712):1072-9.

Hinks et al., 2005

Hinks, A., Barton, A., John, S., Bruce, I., Hawkins, C., Griffiths, C. E., Donn, R., Thomson, W., Silman, A., and Worthington, J. (2005).
Association between the ptpn22 gene and rheumatoid arthritis and juvenile idiopathic arthritis in a uk population: further support that ptpn22 is an autoimmunity gene.
Arthritis Rheum, 52(6):1694-9.

Ho et al., 2005

Ho, P., Bruce, I. N., Silman, A., Symmons, D., Newman, B., Young, H., Griffiths, C. E., John, S., Worthington, J., and Barton, A. (2005).
Evidence for common genetic control in pathways of inflammation for crohn's disease and psoriatic arthritis.
Arthritis Rheum, 52(11):3596-602.

Holgate et al., 2006

Holgate, S. T., Davies, D. E., Powell, R. M., and Holloway, J. W. (2006).
Adam33: a newly identified protease involved in airway remodelling.
Pulm Pharmacol Ther, 19(1):3-11.

Hollox et al., 2008

Hollox, E. J., Huffmeier, U., Zeeuwen, P. L., Palla, R., Lascorz, J., Rodijk-Olthuis, D., van de Kerkhof, P. C., Traupe, H., de Jongh, G., den Heijer, M., Reis, A., Armour, J. A., and Schalkwijk, J. (2008).
Psoriasis is associated with increased beta-defensin genomic copy number.
Nat Genet, 40(1):23-5.

Horai et al., 2004

Horai, R., Nakajima, A., Habiro, K., Kotani, M., Nakae, S., Matsuki, T., Nambu, A., Saijo, S., Kotaki, H., Sudo, K., Okahara, A., Tanioka, H., Ikuse, T., Ishii, N., Schwartzberg, P. L., Abe, R., and Iwakura, Y. (2004).
Tnf-alpha is crucial for the development of autoimmune arthritis in il-1 receptor antagonist-deficient mice.
J Clin Invest, 114(11):1603-11.

Horvath et al., 2001

Horvath, S., Xu, X., and Laird, N. M. (2001).
The family based association test method: strategies for studying general genotype-phenotype associations.
Eur J Hum Genet, 9(4):301-6.

Horvath et al., 2004

Horvath, S., Xu, X., Lake, S. L., Silverman, E. K., Weiss, S. T., and Laird, N. M. (2004).
Family-based tests for associating haplotypes with general phenotype data: application to asthma genetics.
Genet Epidemiol, 26(1):61-9.

Hosomi et al., 2005

Hosomi, N., Fukai, K., Oiso, N., Kato, A., Fukui, M., and Ishii, M. (2005).
No association between atopic dermatitis and the slc9a3r1-nat9 runx1 binding site polymorphism in japanese patients.
Clin Exp Dermatol, 30(2):192-3.

Howard et al., 2003

Howard, T. D., Postma, D. S., Jongepier, H., Moore, W. C., Koppelman, G. H., Zheng, S. L., Xu, J., Bleecker, E. R., and Meyers, D. A. (2003).
Association of a disintegrin and metalloprotease 33 (adam33) gene with asthma in ethnically diverse populations.
J Allergy Clin Immunol, 112(4):717-22.

Huffmeier et al., 2005a

Huffmeier, U., Lascorz, J., Traupe, H., Bohm, B., Schurmeier-Horst, F., Stander, M., Kelsch, R., Baumann, C., Kuster, W., Burkhardt, H., and Reis, A. (2005a).
Systematic linkage disequilibrium analysis of slc12a8 at psors5 confirms a role in susceptibility to psoriasis vulgaris.
J Invest Dermatol, 125(5):906-12.

Huffmeier et al., 2006a

Huffmeier, U., Reis, A., Steffens, M., Lascorz, J., Bohm, B., Lohmann, J., Wendler, J., Traupe, H., Kuster, W., Wienker, T. F., and Burkhardt, H. (2006a).
Male restricted genetic association of variant r620w in ptpn22 with psoriatic arthritis.
J Invest Dermatol, 126(4):932-5.

Huffmeier et al., 2006b

Huffmeier, U., Steffens, M., Burkhardt, H., Lascorz, J., Schurmeier-Horst, F., Stander, M., Kelsch, R., Baumann, C., Kuster, W., Mossner, R., Reich, K., Wienker, T. F., Traupe, H., and Reis, A. (2006b).
Evidence for susceptibility determinant(s) to psoriasis vulgaris in or near ptpn22 in german patients.
J Med Genet, 43(6):517-22.

Huffmeier et al., 2005b

Huffmeier, U., Traupe, H., Burkhardt, H., Schurmeier-Horst, F., Lascorz, J., Bohm, B., Lohmann, J., Stander, M., Wendler, J., Kelsch, R., Baumann, C., Kuster, W., Wienker, T. F., and Reis, A. (2005b).
Lack of evidence for genetic association to runx1 binding site at psors2 in different german psoriasis cohorts.
J Invest Dermatol, 124(1):107-10.

Huffmeier et al., 2007

Huffmeier, U., Traupe, H., Oji, V., Lascorz, J., Stander, M., Lohmann, J., Wendler, J., Burkhardt, H., and Reis, A. (2007).
Loss-of-function variants of the filaggrin gene are not major susceptibility factors for psoriasis vulgaris or psoriatic arthritis in german patients.
J Invest Dermatol, 127(6):1367-70.

Hugot et al., 2001

Hugot, J. P., Chamaillard, M., Zouali, H., Lesage, S., Cezard, J. P., Belaiche, J., Almer, S., Tysk, C., O'Morain, C. A., Gassull, M., Binder, V., Finkel, Y., Cortot, A., Modigliani, R., Laurent-Puig, P., Gower-Rousseau, C., Macry, J., Colombel, J. F., Sahbatou, M., and Thomas, G. (2001).
Association of nod2 leucine-rich repeat variants with susceptibility to crohn's disease.
Nature, 411(6837):599-603.

Hwu et al., 2005

Hwu, W. L., Yang, C. F., Fann, C. S., Chen, C. L., Tsai, T. F., Chien, Y. H., Chiang, S. C., Chen, C. H., Hung, S. I., Wu, J. Y., and Chen, Y. T. (2005).
Mapping of psoriasis to 17q terminus.
J Med Genet, 42(2):152-8.

Ishihara et al., 1996

Ishihara, M., Yamagata, N., Ohno, S., Naruse, T., Ando, A., Kawata, H., Ozawa, A., Ohkido, M., Mizuki, N., Shiina, T., Ando, H., and Inoko, H. (1996).
Genetic polymorphisms in the keratin-like s gene within the human major histocompatibility complex and association analysis on the susceptibility to psoriasis vulgaris.
Tissue Antigens, 48(3):182-6.

Janeway et al., 2003

Janeway, C., Travers, P., Walport, M., Duverlie, G., Shlomchik, M., and Masson, P. (2003).
Immunobiologie, chapter 8, page 296.
de boeck.

Jenisch et al., 2006

Jenisch, S., Hampe, J., Elder, J. T., Nair, R., Stuart, P., Voorhees, J. J., Schreiber, S., Kabelitz, D., Christophers, E., and Weichenthal, M. (2006).
Card15 mutations in patients with plaque-type psoriasis and psoriatic arthritis: lack of association.
Arch Dermatol Res, 297(9):409-11.

Jenisch et al., 1998

Jenisch, S., Henseler, T., Nair, R. P., Guo, S. W., Westphal, E., Stuart, P., Kronke, M., Voorhees, J. J., Christophers, E., and Elder, J. T. (1998).
Linkage analysis of human leukocyte antigen (hla) markers in familial psoriasis: strong disequilibrium effects provide evidence for a major determinant in the hla-b/-c region.
Am J Hum Genet, 63(1):191-9.

Jenisch et al., 1999

Jenisch, S., Koch, S., Henseler, T., Nair, R. P., Elder, J. T., Watts, C. E., Westphal, E., Voorhees, J. J., Christophers, E., and Kronke, M. (1999).
Corneodesmosin gene polymorphism demonstrates strong linkage disequilibrium with hla and association with psoriasis vulgaris.
Tissue Antigens, 54(5):439-49.

JK. and RC., 1972

JK., H. and RC., E. (1972).
The investigation of linkage between a quantitative trait and a marker locus.
Behav Genet, 2(1):3-19.

Julier et al., 1991

Julier, C., Hyer, R. N., Davies, J., Merlin, F., Soularue, P., Briant, L., Cathelineau, G., Deschamps, I., Rotter, J. I., Froguel, P., and et al. (1991).
Insulin-igf2 region on chromosome 11p encodes a gene implicated in hla-dr4-dependent diabetes susceptibility.
Nature, 354(6349):155-9.

Kaijzel et al., 2002

Kaijzel, E. L., van Dongen, H., Bakker, A. M., Breedveld, F. C., Huizinga, T. W., and Verweij, C. L. (2002).
Relationship of polymorphisms of the interleukin-1 gene cluster to occurrence and severity of rheumatoid arthritis.
Tissue Antigens, 59(2):122-6.

Karason et al., 2005

Karason, A., Gudjonsson, J. E., Jonsson, H. H., Hauksson, V. B., Runarsdottir, E. H., Stefansson, K., Valdimarsson, H., and Gulcher, J. R. (2005).
Genetics of psoriasis in iceland: evidence for linkage of subphenotypes to distinct loci.
J Invest Dermatol, 124(6):1177-85.

Karason et al., 2003

Karason, A., Gudjonsson, J. E., Upmanyu, R., Antonsdottir, A. A., Hauksson, V. B., Runasdottir, E. H., Jonsson, H. H., Gudbjartsson, D. F., Frigge, M. L., Kong, A., Stefansson, K., Valdimarsson, H., and Gulcher, J. R. (2003).
A susceptibility gene for psoriatic arthritis maps to chromosome 16q: evidence for imprinting.
Am J Hum Genet, 72(1):125-31.

Kauppi et al., 2001

Kauppi, P., Lindblad-Toh, K., Sevon, P., Toivonen, H. T., Rioux, J. D., Villapakkam, A., Laitinen, L. A., Hudson, T. J., Kere, J., and Laitinen, T. (2001).
A second-generation association study of the 5q31 cytokine gene cluster and the interleukin-4 receptor in asthma.
Genomics, 77(1-2):35-42.

Khoury, 1994

Khoury, M. J. (1994).
Case-parental control method in the search for disease-susceptibility genes.
Am J Hum Genet, 55(2):414-5.

Kirby et al., 2001

Kirby, B., Richards, H. L., Woo, P., Hindle, E., Main, C. J., and Griffiths, C. E. (2001).
Physical and psychologic measures are necessary to assess overall psoriasis severity.
J Am Acad Dermatol, 45(1):72-6.

Knapp, 1999

Knapp, M. (1999).
A note on power approximations for the transmission/disequilibrium test.
Am J Hum Genet, 64(4):1177-85.

Kornman et al., 1997

Kornman, K. S., Crane, A., Wang, H. Y., di Giovine, F. S., Newman, M. G., Pirk, F. W., Wilson, T. G., J., Higginbottom, F. L., and Duff, G. W. (1997).
The interleukin-1 genotype as a severity factor in adult periodontal disease.
J Clin Periodontol, 24(1):72-7.

Krueger and Duvic, 1994

Krueger, G. G. and Duvic, M. (1994).
Epidemiology of psoriasis: clinical issues.
J Invest Dermatol, 102(6):14S-18S.

Kruglyak, 1999

Kruglyak, L. (1999).
Prospects for whole-genome linkage disequilibrium mapping of common disease genes.
Nat Genet, 22(2):139-44.

Kruglyak et al., 1996

Kruglyak, L., Daly, M. J., Reeve-Daly, M. P., and Lander, E. S. (1996).
Parametric and nonparametric linkage analysis: a unified multipoint approach.
Am J Hum Genet, 58(6):1347-63.

Kruglyak and Nickerson, 2001

Kruglyak, L. and Nickerson, D. A. (2001).
Variation is the spice of life.
Nat Genet, 27(3):234-6.

Kyogoku et al., 2004

Kyogoku, C., Langefeld, C. D., Ortmann, W. A., Lee, A., Selby, S., Carlton, V. E., Chang, M., Ramos, P., Baechler, E. C., Batliwalla, F. M., Novitzke, J., Williams, A. H., Gillett, C., Rodine, P., Graham, R. R., Ardlie, K. G., Gaffney, P. M., Moser, K. L., Petri, M., Begovich, A. B., Gregersen, P. K., and Behrens, T. W. (2004).
Genetic association of the r620w polymorphism of protein tyrosine phosphatase ptpn22 with human sle.
Am J Hum Genet, 75(3):504-7.

Laird et al., 2000

Laird, N. M., Horvath, S., and Xu, X. (2000).
Implementing a unified approach to family-based tests of association.
Genet Epidemiol, 19 Suppl 1:S36-42.

Lamoril et al., 2007

Lamoril, J., Deybach, J., and Bouizegarèneb, P. (2007).
Genetic aspects of crohn’s disease: a review.
Immuno-analyse et bio spécialisée, 22(3):137–150.

Lander and Kruglyak, 1995

Lander, E. and Kruglyak, L. (1995).
Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results.
Nat Genet, 11(3):241-7.

Lange and Laird, 2002

Lange, C. and Laird, N. M. (2002).
Power calculations for a general class of family-based association tests: dichotomous traits.
Am J Hum Genet, 71(3):575-84.

Larko, 1995

Larko, O. (1995).
Problem sites: scalp, palm and sole, and nail.
Dermatol Clin, 13(4):771-7.

Lascorz et al., 2005

Lascorz, J., Burkhardt, H., Huffmeier, U., Bohm, B., Schurmeyer-Horst, F., Lohmann, J., Stander, M., Wendler, J., Kelsch, R., Baumann, C., Kuster, W., Traupe, H., and Reis, A. (2005).
Lack of genetic association of the three more common polymorphisms of card15 with psoriatic arthritis and psoriasis in a german cohort.
Ann Rheum Dis, 64(6):951-4.

Lathrop et al., 1984

Lathrop, G. M., Lalouel, J. M., Julier, C., and Ott, J. (1984).
Strategies for multilocus linkage analysis in humans.
Proc Natl Acad Sci U S A, 81(11):3443-6.

Lavaroni et al., 1994

Lavaroni, G., Kokelj, F., Pauluzzi, P., and Trevisan, G. (1994).
The nails in psoriatic arthritis.
Acta Derm Venereol Suppl (Stockh), 186:113.

Lazzeroni and Lange, 1998

Lazzeroni, L. C. and Lange, K. (1998).
A conditional inference framework for extending the transmission/disequilibrium test.
Hum Hered, 48(2):67-81.

Lee et al., 1990

Lee, F. I., Bellary, S. V., and Francis, C. (1990).
Increased occurrence of psoriasis in patients with crohn's disease and their relatives.
Am J Gastroenterol, 85(8):962-3.

Lee et al., 2002

Lee, J. K., Park, C., Kimm, K., and Rutherford, M. S. (2002).
Genome-wide multilocus analysis for immune-mediated complex diseases.
Biochem Biophys Res Commun, 295(4):771-3.

Lee et al., 2000

Lee, Y. A., Ruschendorf, F., Windemuth, C., Schmitt-Egenolf, M., Stadelmann, A., Nurnberg, G., Stander, M., Wienker, T. F., Reis, A., and Traupe, H. (2000).
Genomewide scan in german families reveals evidence for a novel psoriasis-susceptibility locus on chromosome 19p13.
Am J Hum Genet, 67(4):1020-4.

Lee et al., 2007

Lee, Y. H., Rho, Y. H., Choi, S. J., Ji, J. D., Song, G. G., Nath, S. K., and Harley, J. B. (2007).
The ptpn22 c1858t functional polymorphism and autoimmune diseases-a meta-analysis.
Rheumatology (Oxford), 46(1):49-56.

Lench et al., 2005

Lench, N., Iles, M. M., Mackay, I., Patel, R., Sagoo, G. S., Ward, S. J., Dechairo, B., Olavesen, M., Carey, A., Duff, G. W., Cork, M. J., and Tazi-Ahnini, R. (2005).
Single-point haplotype scores telomeric to human leukocyte antigen-c give a high susceptibility major histocompatability complex haplotype for psoriasis in a caucasian population.
J Invest Dermatol, 124(3):545-52.

Lesueur et al., 2007a

Lesueur, F., Lefevre, C., Has, C., Guilloud-Bataille, M., Oudot, T., Mahe, E., Lahfa, M., Mansouri, S., Mosharraf-Olmolk, H., Sobel, E., Heath, S., Lathrop, M., Dizier, M. H., Prud'Homme, J. F., and Fischer, J. (2007a).
Confirmation of psoriasis susceptibility loci on chromosome 6p21 and 20p13 in french families.
J Invest Dermatol, 127(6):1403-9.

Lesueur et al., 2007b

Lesueur, F., Oudot, T., Heath, S., Foglio, M., Lathrop, M., Prud'homme, J. F., and Fischer, J. (2007b).
Adam33, a new candidate for psoriasis susceptibility.
PLoS ONE, 2(9):e906.

Lew et al., 2004

Lew, W., Bowcock, A. M., and Krueger, J. G. (2004).
Psoriasis vulgaris: cutaneous lymphoid tissue supports t-cell activation and "type 1" inflammatory gene expression.
Trends Immunol, 25(6):295-305.

Li et al., 2008

Li, Y., Liao, W., Chang, M., Schrodi, S. J., Bui, N., Catanese, J. J., Poon, A., Matsunami, N., Callis-Duffin, K. P., Leppert, M. F., Bowcock, A. M., Kwok, P. Y., Krueger, G. G., and Begovich, A. B. (2008).
Further genetic evidence for three psoriasis-risk genes: Adam33, cdkal1, and ptpn22.
J Invest Dermatol.

Liu et al., 2008

Liu, Y., Helms, C., Liao, W., Zaba, L. C., Duan, S., Gardner, J., Wise, C., Miner, A., Malloy, M. J., Pullinger, C. R., Kane, J. P., Saccone, S., Worthington, J., Bruce, I., Kwok, P. Y., Menter, A., Krueger, J., Barton, A., Saccone, N. L., and Bowcock, A. M. (2008).
A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci.
PLoS Genet, 4(3):e1000041.

Liu et al., 2007

Liu, Y., Krueger, J. G., and Bowcock, A. M. (2007).
Psoriasis: genetic associations and immune system changes.
Genes Immun, 8(1):1-12.

Lord et al., 1991

Lord, P. C., Wilmoth, L. M., Mizel, S. B., and McCall, C. E. (1991).
Expression of interleukin-1 alpha and beta genes by human blood polymorphonuclear leukocytes.
J Clin Invest, 87(4):1312-21.

Los et al., 1999

Los, H., Koppelman, G., and Postma, D. (1999).
The importance of genetic influence in asthma.
Eur Resp J, 14:1210-1227.

Lowes et al., 2007

Lowes, M. A., Bowcock, A. M., and Krueger, J. G. (2007).
Pathogenesis and therapy of psoriasis.
Nature, 445(7130):866-73.

Maeda et al., 2005

Maeda, S., Hsu, L. C., Liu, H., Bankston, L. A., Iimura, M., Kagnoff, M. F., Eckmann, L., and Karin, M. (2005).
Nod2 mutation in crohn's disease potentiates nf-kappab activity and il-1beta processing.
Science, 307(5710):734-8.

Mahe et al., 2002

Mahe, E., Lahfa, M., Mansouri, S., Mosharraf-Olmolk, H., Le Rebours, J., Prud'Homme, J. F., and Fischer, J. (2002).
Physicians' response to a letter to confirm diagnosis in a genetic study of psoriasis.
Eur J Dermatol, 12(1):66-9.

Mallon et al., 2000

Mallon, E., Bunce, M., Savoie, H., Rowe, A., Newson, R., Gotch, F., and Bunker, C. B. (2000).
Hla-c and guttate psoriasis.
Br J Dermatol, 143(6):1177-82.

Mallon et al., 1997

Mallon, E., Bunce, M., Wojnarowska, F., and Welsh, K. (1997).
Hla-cw*0602 is a susceptibility factor in type i psoriasis, and evidence ala-73 is increased in male type i psoriatics.
J Invest Dermatol, 109(2):183-6.

Mallon and Bunker, 2000

Mallon, E. and Bunker, C. B. (2000).
Hiv-associated psoriasis.
AIDS Patient Care STDS, 14(5):239-46.

Mallon et al., 1999

Mallon, E., Newson, R., and Bunker, C. B. (1999).
Hla-cw6 and the genetic predisposition to psoriasis: a meta-analysis of published serologic studies.
J Invest Dermatol, 113(4):693-5.

Marenholz et al., 2006

Marenholz, I., Nickel, R., Ruschendorf, F., Schulz, F., Esparza-Gordillo, J., Kerscher, T., Gruber, C., Lau, S., Worm, M., Keil, T., Kurek, M., Zaluga, E., Wahn, U., and Lee, Y. A. (2006).
Filaggrin loss-of-function mutations predispose to phenotypes involved in the atopic march.
J Allergy Clin Immunol, 118(4):866-71.

Martinez-Borra et al., 2005

Martinez-Borra, J., Brautbar, C., Gonzalez, S., Enk, C. D., Lopez-Vazquez, A., and Lopez-Larrea, C. (2005).
The region of 150 kb telometic to hla-c is associated with psoriasis in the jewish population.
J Invest Dermatol, 125(5):928-32.

Matthews et al., 1996

Matthews, D., Fry, L., Powles, A., Weber, J., McCarthy, M., Fisher, E., Davies, K., and Williamson, R. (1996).
Evidence that a locus for familial psoriasis maps to chromosome 4q.
Nat Genet, 14(2):231-3.

McKenzie and Sabin, 2003

McKenzie, R. C. and Sabin, E. (2003).
Aberrant signalling and transcription factor activation as an explanation for the defective growth control and differentiation of keratinocytes in psoriasis: a hypothesis.
Exp Dermatol, 12(4):337-45.

McVean et al., 2004

McVean, G. A., Myers, S. R., Hunt, S., Deloukas, P., Bentley, D. R., and Donnelly, P. (2004).
The fine-scale structure of recombination rate variation in the human genome.
Science, 304(5670):581-4.

Mee et al., 2006

Mee, J. B., Cork, M. J., di Giovine, F. S., Duff, G. W., and Groves, R. W. (2006).
Interleukin-1: a key inflammatory mediator in psoriasis?
Cytokine, 33(2):72-8.

Monpetit and Chagnon, 2006

Monpetit, A. and Chagnon, F. (2006).
La carte d'haplotype du génome humain.
med sci, 22(12):1061-68.

Morahan et al., 2001

Morahan, G., Huang, D., Ymer, S. I., Cancilla, M. R., Stephen, K., Dabadghao, P., Werther, G., Tait, B. D., Harrison, L. C., and Colman, P. G. (2001).
Linkage disequilibrium of a type 1 diabetes susceptibility locus with a regulatory il12b allele.
Nat Genet, 27(2):218-21.

Morar et al., 2006

Morar, N., Bowcock, A. M., Harper, J. I., Cookson, W. O., and Moffatt, M. F. (2006).
Investigation of the chromosome 17q25 psors2 locus in atopic dermatitis.
J Invest Dermatol, 126(3):603-6.

Morton, 1955

Morton, N. E. (1955).
Sequential tests for the detection of linkage.
Am J Hum Genet, 7(3):277-318.

Mukhopadhyay et al., 2005

Mukhopadhyay, N., Almasy, L., Schroeder, M., Mulvihill, W. P., and Weeks, D. E. (2005).
Mega2: data-handling for facilitating genetic linkage and association analyses.
Bioinformatics, 21(10):2556-7.

Nair et al., 1995

Nair, R. P., Guo, S. W., Jenisch, S., Henseler, T., Lange, E. M., Terhune, M., Westphal, E., Christophers, E., Voorhees, J. J., and Elder, J. T. (1995).
Scanning chromosome 17 for psoriasis susceptibility: lack of evidence for a distal 17q locus.
Hum Hered, 45(4):219-30.

Nair et al., 1997

Nair, R. P., Henseler, T., Jenisch, S., Stuart, P., Bichakjian, C. K., Lenk, W., Westphal, E., Guo, S. W., Christophers, E., Voorhees, J. J., and Elder, J. T. (1997).
Evidence for two psoriasis susceptibility loci (hla and 17q) and two novel candidate regions (16q and 20p) by genome-wide scan.
Hum Mol Genet, 6(8):1349-56.

Nair et al., 2008

Nair, R. P., Ruether, A., Stuart, P. E., Jenisch, S., Tejasvi, T., Hiremagalore, R., Schreiber, S., Kabelitz, D., Lim, H. W., Voorhees, J. J., Christophers, E., Elder, J. T., and Weichenthal, M. (2008).
Polymorphisms of the il12b and il23r genes are associated with psoriasis.
J Invest Dermatol, 128(7):1653-61.

Nair et al., 2000

Nair, R. P., Stuart, P., Henseler, T., Jenisch, S., Chia, N. V., Westphal, E., Schork, N. J., Kim, J., Lim, H. W., Christophers, E., Voorhees, J. J., and Elder, J. T. (2000).
Localization of psoriasis-susceptibility locus psors1 to a 60-kb interval telomeric to hla-c.
Am J Hum Genet, 66(6):1833-44.

Nair et al., 2001

Nair, R. P., Stuart, P., Ogura, Y., Inohara, N., Chia, N. V., Young, L., Henseler, T., Jenisch, S., Christophers, E., Voorhees, J. J., Nunez, G., and Elder, J. T. (2001).
Lack of association between nod2 3020insc frameshift mutation and psoriasis.
J Invest Dermatol, 117(6):1671-2.

Nair et al., 2006

Nair, R. P., Stuart, P. E., Nistor, I., Hiremagalore, R., Chia, N. V., Jenisch, S., Weichenthal, M., Abecasis, G. R., Lim, H. W., Christophers, E., Voorhees, J. J., and Elder, J. T. (2006).
Sequence and haplotype analysis supports hla-c as the psoriasis susceptibility 1 gene.
Am J Hum Genet, 78(5):827-51.

Naldi et al., 2001

Naldi, L., Peli, L., Parazzini, F., and Carrel, C. F. (2001).
Family history of psoriasis, stressful life events, and recent infectious disease are risk factors for a first episode of acute guttate psoriasis: results of a case-control study.
J Am Acad Dermatol, 44(3):433-8.

Newman et al., 2005a

Newman, B., Gu, X., Wintle, R., Cescon, D., Yazdanpanah, M., Liu, X., Peltekova, V., Van Oene, M., Amos, C. I., and Siminovitch, K. A. (2005a).
A risk haplotype in the solute carrier family 22a4/22a5 gene cluster influences phenotypic expression of crohn's disease.
Gastroenterology, 128(2):260-9.

Newman et al., 2005b

Newman, B., Wintle, R. F., van Oene, M., Yazdanpanah, M., Owen, J., Johnson, B., Gu, X., Amos, C. I., Keystone, E., Rubin, L. A., and Siminovitch, K. A. (2005b).
Slc22a4 polymorphisms implicated in rheumatoid arthritis and crohn's disease are not associated with rheumatoid arthritis in a canadian caucasian population.
Arthritis Rheum, 52(2):425-9.

Newman et al., 2001

Newman, D. L., Abney, M., McPeek, M. S., Ober, C., and Cox, N. J. (2001).
The importance of genealogy in determining genetic associations with complex traits.
Am J Hum Genet, 69(5):1146-8.

Nistor et al., 2005

Nistor, I., Nair, R. P., Stuart, P., Hiremagalore, R., Thompson, R. A., Jenisch, S., Weichenthal, M., Abecasis, G. R., Qin, Z. S., Christophers, E., Lim, H. W., Voorhees, J. J., and Elder, J. T. (2005).
Protein tyrosine phosphatase gene ptpn22 polymorphism in psoriasis: lack of evidence for association.
J Invest Dermatol, 125(2):395-6.

Nomura et al., 2008

Nomura, T., Akiyama, M., Sandilands, A., Nemoto-Hasebe, I., Sakai, K., Nagasaki, A., Ota, M., Hata, H., Evans, A. T., Palmer, C. N., Shimizu, H., and McLean, W. H. (2008).
Specific filaggrin mutations cause ichthyosis vulgaris and are significantly associated with atopic dermatitis in japan.
J Invest Dermatol, 128(6):1436-41.

O'Brien et al., 2001

O'Brien, K. P., Holm, S. J., Nilsson, S., Carlen, L., Rosenmuller, T., Enerback, C., Inerot, A., and Stahle-Backdahl, M. (2001).
The hcr gene on 6p21 is unlikely to be a psoriasis susceptibility gene.
J Invest Dermatol, 116(5):750-4.

Ockenfels, 2003

Ockenfels, H. M. (2003).
[trigger factors for psoriasis].
Hautarzt, 54(3):215-23.

O'Connell and Weeks, 1998

O'Connell, J. R. and Weeks, D. E. (1998).
Pedcheck: a program for identification of genotype incompatibilities in linkage analysis.
Am J Hum Genet, 63(1):259-66.

Ogura et al., 2001

Ogura, Y., Bonen, D. K., Inohara, N., Nicolae, D. L., Chen, F. F., Ramos, R., Britton, H., Moran, T., Karaliuskas, R., Duerr, R. H., Achkar, J. P., Brant, S. R., Bayless, T. M., Kirschner, B. S., Hanauer, S. B., Nunez, G., and Cho, J. H. (2001).
A frameshift mutation in nod2 associated with susceptibility to crohn's disease.
Nature, 411(6837):603-6.

Ogura et al., 2003

Ogura, Y., Saab, L., Chen, F. F., Benito, A., Inohara, N., and Nunez, G. (2003).
Genetic variation and activity of mouse nod2, a susceptibility gene for crohn's disease.
Genomics, 81(4):369-77.

Oka et al., 1999

Oka, A., Tamiya, G., Tomizawa, M., Ota, M., Katsuyama, Y., Makino, S., Shiina, T., Yoshitome, M., Iizuka, M., Sasao, Y., Iwashita, K., Kawakubo, Y., Sugai, J., Ozawa, A., Ohkido, M., Kimura, M., Bahram, S., and Inoko, H. (1999).
Association analysis using refined microsatellite markers localizes a susceptibility locus for psoriasis vulgaris within a 111 kb segment telomeric to the hla-c gene.
Hum Mol Genet, 8(12):2165-70.

Orru et al., 2005

Orru, S., Giuressi, E., Carcassi, C., Casula, M., and Contu, L. (2005).
Mapping of the major psoriasis-susceptibility locus (psors1) in a 70-kb interval around the corneodesmosin gene (cdsn).
Am J Hum Genet, 76(1):164-71.

Ortonne and Ortonne, 1999

Ortonne, N. and Ortonne, J. P. (1999).
[psoriasis. pathogenesis].
Presse Med, 28(23):1259-65.

Palmer et al., 2006

Palmer, C. N., Irvine, A. D., Terron-Kwiatkowski, A., Zhao, Y., Liao, H., Lee, S. P., Goudie, D. R., Sandilands, A., Campbell, L. E., Smith, F. J., O'Regan, G. M., Watson, R. M., Cecil, J. E., Bale, S. J., Compton, J. G., DiGiovanna, J. J., Fleckman, P., Lewis-Jones, S., Arseculeratne, G., Sergeant, A., Munro, C. S., El Houate, B., McElreavey, K., Halkjaer, L. B., Bisgaard, H., Mukhopadhyay, S., and McLean, W. H. (2006).
Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis.
Nat Genet, 38(4):441-6.

Palmer et al., 2007

Palmer, C. N., Ismail, T., Lee, S. P., Terron-Kwiatkowski, A., Zhao, Y., Liao, H., Smith, F. J., McLean, W. H., and Mukhopadhyay, S. (2007).
Filaggrin null mutations are associated with increased asthma severity in children and young adults.
J Allergy Clin Immunol, 120(1):64-8.

Panet and Atlan, 1991

Panet, R. and Atlan, H. (1991).
Stimulation of bumetanide-sensitive na+/k+/cl- cotransport by different mitogens in synchronized human skin fibroblasts is essential for cell proliferation.
J Cell Biol, 114(2):337-42.

Passarge, 2000

Passarge, E. (2000).
Atlas de poche de Génétique, page 56.
Médecine-Sciences, Flammarion.

Peddle et al., 2005

Peddle, L., Butt, C., Snelgrove, T., and Rahman, P. (2005).
Interleukin (il) 1alpha, il1beta, il receptor antagonist, and il10 polymorphisms in psoriatic arthritis.
Ann Rheum Dis, 64(7):1093-4.

Peltekova et al., 2004

Peltekova, V. D., Wintle, R. F., Rubin, L. A., Amos, C. I., Huang, Q., Gu, X., Newman, B., Van Oene, M., Cescon, D., Greenberg, G., Griffiths, A. M., St George-Hyslop, P. H., and Siminovitch, K. A. (2004).
Functional variants of octn cation transporter genes are associated with crohn disease.
Nat Genet, 36(5):471-5.

Penrose, 1935

Penrose, L. (1935).
The detection of autosomal linkage in data which consists of pairs of brothers and sisters of unspecified parentage.
Ann Eugen, 6:133-38.

Pietrzak et al., 2008

Pietrzak, A. T., Zalewska, A., Chodorowska, G., Krasowska, D., Michalak-Stoma, A., Nockowski, P., Osemlak, P., Paszkowski, T., and Rolinski, J. M. (2008).
Cytokines and anticytokines in psoriasis.
Clin Chim Acta, 394(1-2):7-21.

Pietrzyk et al., 1982

Pietrzyk, J. J., Turowski, G., Kapinska-Mrowka, M., and Rozanski, B. (1982).
Family studies in psoriasis. i. complex segregation analysis.
Arch Dermatol Res, 273(3-4):287-94.

Plant et al., 2004

Plant, D., Lear, J., Marsland, A., Worthington, J., and Griffiths, C. E. (2004).
Card15/nod2 single nucleotide polymorphisms do not confer susceptibility to type i psoriasis.
Br J Dermatol, 151(3):675-8.

Presky et al., 1996

Presky, D. H., Yang, H., Minetti, L. J., Chua, A. O., Nabavi, N., Wu, C. Y., Gately, M. K., and Gubler, U. (1996).
A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits.
Proc Natl Acad Sci U S A, 93(24):14002-7.

Prinz, 2003

Prinz, J. C. (2003).
The role of t cells in psoriasis.
J Eur Acad Dermatol Venereol, 17(3):257-70.

Prokunina et al., 2002

Prokunina, L., Castillejo-Lopez, C., Oberg, F., Gunnarsson, I., Berg, L., Magnusson, V., Brookes, A. J., Tentler, D., Kristjansdottir, H., Grondal, G., Bolstad, A. I., Svenungsson, E., Lundberg, I., Sturfelt, G., Jonssen, A., Truedsson, L., Lima, G., Alcocer-Varela, J., Jonsson, R., Gyllensten, U. B., Harley, J. B., Alarcon-Segovia, D., Steinsson, K., and Alarcon-Riquelme, M. E. (2002).
A regulatory polymorphism in pdcd1 is associated with susceptibility to systemic lupus erythematosus in humans.
Nat Genet, 32(4):666-9.

Rabinowitz and Laird, 2000

Rabinowitz, D. and Laird, N. (2000).
A unified approach to adjusting association tests for population admixture with arbitrary pedigree structure and arbitrary missing marker information.
Hum Hered, 50(4):211-23.

Rahman et al., 2003

Rahman, P., Bartlett, S., Siannis, F., Pellett, F. J., Farewell, V. T., Peddle, L., Schentag, C. T., Alderdice, C. A., Hamilton, S., Khraishi, M., Tobin, Y., Hefferton, D., and Gladman, D. D. (2003).
Card15: a pleiotropic autoimmune gene that confers susceptibility to psoriatic arthritis.
Am J Hum Genet, 73(3):677-81.

Rahman et al., 2006

Rahman, P., Sun, S., Peddle, L., Snelgrove, T., Melay, W., Greenwood, C., and Gladman, D. (2006).
Association between the interleukin-1 family gene cluster and psoriatic arthritis.
Arthritis Rheum, 54(7):2321-5.

Randolph et al., 2004

Randolph, A. G., Lange, C., Silverman, E. K., Lazarus, R., Silverman, E. S., Raby, B., Brown, A., Ozonoff, A., Richter, B., and Weiss, S. T. (2004).
The il12b gene is associated with asthma.
Am J Hum Genet, 75(4):709-15.

Rauschmayr et al., 1997

Rauschmayr, T., Groves, R. W., and Kupper, T. S. (1997).
Keratinocyte expression of the type 2 interleukin 1 receptor mediates local and specific inhibition of interleukin 1-mediated inflammation.
Proc Natl Acad Sci U S A, 94(11):5814-9.

Ravindran et al., 2004

Ravindran, J. S., Owen, P., Lagan, A., Lewis, J., Korendowych, E., Welsh, K., and McHugh, N. (2004).
Interleukin 1alpha, interleukin 1beta and interleukin 1 receptor gene polymorphisms in psoriatic arthritis.
Rheumatology (Oxford), 43(1):22-6.

Raychaudhuri and Gross, 2000a

Raychaudhuri, S. P. and Gross, J. (2000a).
A comparative study of pediatric onset psoriasis with adult onset psoriasis.
Pediatr Dermatol, 17(3):174-8.

Raychaudhuri and Gross, 2000b

Raychaudhuri, S. P. and Gross, J. (2000b).
Psoriasis risk factors: role of lifestyle practices.
Cutis, 66(5):348-52.

Reich et al., 2002

Reich, K., Mossner, R., Konig, I. R., Westphal, G., Ziegler, A., and Neumann, C. (2002).
Promoter polymorphisms of the genes encoding tumor necrosis factor-alpha and interleukin-1beta are associated with different subtypes of psoriasis characterized by early and late disease onset.
J Invest Dermatol, 118(1):155-63.

Reiley et al., 2004

Reiley, W., Zhang, M., and Sun, S. C. (2004).
Negative regulation of jnk signaling by the tumor suppressor cyld.
J Biol Chem, 279(53):55161-7.

Reiley et al., 2007

Reiley, W. W., Jin, W., Lee, A. J., Wright, A., Wu, X., Tewalt, E. F., Leonard, T. O., Norbury, C. C., Fitzpatrick, L., Zhang, M., and Sun, S. C. (2007).
Deubiquitinating enzyme cyld negatively regulates the ubiquitin-dependent kinase tak1 and prevents abnormal t cell responses.
J Exp Med, 204(6):1475-85.

Reiley et al., 2006

Reiley, W. W., Zhang, M., Jin, W., Losiewicz, M., Donohue, K. B., Norbury, C. C., and Sun, S. C. (2006).
Regulation of t cell development by the deubiquitinating enzyme cyld.
Nat Immunol, 7(4):411-7.

Revillard, 2001

Revillard, J. (2001).
Immunologie, chapter 26, page 386.
De Boeck.

Rioux et al., 2001

Rioux, J. D., Daly, M. J., Silverberg, M. S., Lindblad, K., Steinhart, H., Cohen, Z., Delmonte, T., Kocher, K., Miller, K., Guschwan, S., Kulbokas, E. J., O'Leary, S., Winchester, E., Dewar, K., Green, T., Stone, V., Chow, C., Cohen, A., Langelier, D., Lapointe, G., Gaudet, D., Faith, J., Branco, N., Bull, S. B., McLeod, R. S., Griffiths, A. M., Bitton, A., Greenberg, G. R., Lander, E. S., Siminovitch, K. A., and Hudson, T. J. (2001).
Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to crohn disease.
Nat Genet, 29(2):223-8.

Risch, 1990

Risch, N. (1990).
Linkage strategies for genetically complex traits. ii. the power of affected relative pairs.
Am J Hum Genet, 46(2):229-41.

Risch and Merikangas, 1996

Risch, N. and Merikangas, K. (1996).
The future of genetic studies of complex human diseases.
Science, 273(5281):1516-7.

Risch, 2000

Risch, N. J. (2000).
Searching for genetic determinants in the new millennium.
Nature, 405(6788):847-56.

Romphruk et al., 2003

Romphruk, A. V., Oka, A., Romphruk, A., Tomizawa, M., Choonhakarn, C., Naruse, T. K., Puapairoj, C., Tamiya, G., Leelayuwat, C., and Inoko, H. (2003).
Corneodesmosin gene: no evidence for psors 1 gene in north-eastern thai psoriasis patients.
Tissue Antigens, 62(3):217-24.

Rozen and Skaletsky, 2000

Rozen, S. and Skaletsky, H. (2000).
Primer3 on the www for general users and for biologist programmers.
Methods Mol Biol, 132:365-86.

Ruether et al., 2006

Ruether, A., Stoll, M., Schwarz, T., Schreiber, S., and Folster-Holst, R. (2006).
Filaggrin loss-of-function variant contributes to atopic dermatitis risk in the population of northern germany.
Br J Dermatol, 155(5):1093-4.

Russell et al., 1995

Russell, L. J., DiGiovanna, J. J., Rogers, G. R., Steinert, P. M., Hashem, N., Compton, J. G., and Bale, S. J. (1995).
Mutations in the gene for transglutaminase 1 in autosomal recessive lamellar ichthyosis.
Nat Genet, 9(3):279-83.

Sagoo et al., 2004

Sagoo, G. S., Tazi-Ahnini, R., Barker, J. W., Elder, J. T., Nair, R. P., Samuelsson, L., Traupe, H., Trembath, R. C., Robinson, D. A., and Iles, M. M. (2004).
Meta-analysis of genome-wide studies of psoriasis susceptibility reveals linkage to chromosomes 6p21 and 4q28-q31 in caucasian and chinese hans population.
J Invest Dermatol, 122(6):1401-5.

Samuelsson et al., 1999

Samuelsson, L., Enlund, F., Torinsson, A., Yhr, M., Inerot, A., Enerback, C., Wahlstrom, J., Swanbeck, G., and Martinsson, T. (1999).
A genome-wide search for genes predisposing to familial psoriasis by using a stratification approach.
Hum Genet, 105(6):523-9.

Sandilands et al., 2006

Sandilands, A., O'Regan, G. M., Liao, H., Zhao, Y., Terron-Kwiatkowski, A., Watson, R. M., Cassidy, A. J., Goudie, D. R., Smith, F. J., McLean, W. H., and Irvine, A. D. (2006).
Prevalent and rare mutations in the gene encoding filaggrin cause ichthyosis vulgaris and predispose individuals to atopic dermatitis.
J Invest Dermatol, 126(8):1770-5.

Sano et al., 2005

Sano, S., Chan, K. S., Carbajal, S., Clifford, J., Peavey, M., Kiguchi, K., Itami, S., Nickoloff, B. J., and DiGiovanni, J. (2005).
Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model.
Nat Med, 11(1):43-9.

Sano et al., 2008

Sano, S., Chan, K. S., and DiGiovanni, J. (2008).
Impact of stat3 activation upon skin biology: a dichotomy of its role between homeostasis and diseases.
J Dermatol Sci, 50(1):1-14.

Saunders et al., 1993

Saunders, A. M., Strittmatter, W. J., Schmechel, D., George-Hyslop, P. H., Pericak-Vance, M. A., Joo, S. H., Rosi, B. L., Gusella, J. F., Crapper-MacLachlan, D. R., Alberts, M. J., and et al. (1993).
Association of apolipoprotein e allele epsilon 4 with late-onset familial and sporadic alzheimer's disease.
Neurology, 43(8):1467-72.

Schmitt-Egenolf et al., 2001

Schmitt-Egenolf, M., Windemuth, C., Hennies, H. C., Albis-Camps, M., von Engelhardt, B., Wienker, T., Reis, A., Traupe, H., and Blasczyk, R. (2001).
Comparative association analysis reveals that corneodesmosin is more closely associated with psoriasis than hla-cw*0602-b*5701 in german families.
Tissue Antigens, 57(5):440-6.

Schrijver et al., 1999

Schrijver, H. M., Crusius, J. B., Uitdehaag, B. M., Garcia Gonzalez, M. A., Kostense, P. J., Polman, C. H., and Pena, A. S. (1999).
Association of interleukin-1beta and interleukin-1 receptor antagonist genes with disease severity in ms.
Neurology, 52(3):595-9.

Seboun, 1996

Seboun, E. (1996).
Etude des facteurs génétiques d'une maladie à hérédité complexe: la sclérose en plaques.
Ann Instit Pasteur, 7(1):37-41.

Shaker et al., 2006

Shaker, O. G., Moustafa, W., Essmat, S., Abdel-Halim, M., and El-Komy, M. (2006).
The role of interleukin-12 in the pathogenesis of psoriasis.
Clin Biochem, 39(2):119-25.

Shaulian and Karin, 2002

Shaulian, E. and Karin, M. (2002).
Ap-1 as a regulator of cell life and death.
Nat Cell Biol, 4(5):E131-6.

Shepherd et al., 2004

Shepherd, J., Little, M. C., and Nicklin, M. J. (2004).
Psoriasis-like cutaneous inflammation in mice lacking interleukin-1 receptor antagonist.
J Invest Dermatol, 122(3):665-9.

Simon et al., 1997

Simon, M., Montezin, M., Guerrin, M., Durieux, J. J., and Serre, G. (1997).
Characterization and purification of human corneodesmosin, an epidermal basic glycoprotein associated with corneocyte-specific modified desmosomes.
J Biol Chem, 272(50):31770-6.

Siroux et al., 2008

Siroux, V., Bouzigon, E., Dizier, M. H., Pin, I., Demenais, F., and Kauffmann, F. (2008).
Replication of association between adam33 polymorphisms and psoriasis.
PLoS ONE, 3(6):e2448.

Skov and Baadsgaard, 2000

Skov, L. and Baadsgaard, O. (2000).
Bacterial superantigens and inflammatory skin diseases.
Clin Exp Dermatol, 25(1):57-61.

Smith et al., 2006

Smith, F. J., Irvine, A. D., Terron-Kwiatkowski, A., Sandilands, A., Campbell, L. E., Zhao, Y., Liao, H., Evans, A. T., Goudie, D. R., Lewis-Jones, S., Arseculeratne, G., Munro, C. S., Sergeant, A., O'Regan, G., Bale, S. J., Compton, J. G., DiGiovanna, J. J., Presland, R. B., Fleckman, P., and McLean, W. H. (2006).
Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris.
Nat Genet, 38(3):337-42.

Smith et al., 2008

Smith, R. L., Warren, R. B., Eyre, S., Ke, X., Young, H. S., Allen, M., Strachan, D., McArdle, W., Gittins, M. P., Barker, J. N., Griffiths, C. E., and Worthington, J. (2008).
Polymorphisms in the ptpn22 region are associated with psoriasis of early onset.
Br J Dermatol, 158(5):962-8.

Smyth et al., 2004

Smyth, D., Cooper, J. D., Collins, J. E., Heward, J. M., Franklyn, J. A., Howson, J. M., Vella, A., Nutland, S., Rance, H. E., Maier, L., Barratt, B. J., Guja, C., Ionescu-Tirgoviste, C., Savage, D. A., Dunger, D. B., Widmer, B., Strachan, D. P., Ring, S. M., Walker, N., Clayton, D. G., Twells, R. C., Gough, S. C., and Todd, J. A. (2004).
Replication of an association between the lymphoid tyrosine phosphatase locus (lyp/ptpn22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus.
Diabetes, 53(11):3020-3.

Sobel and Lange, 1996

Sobel, E. and Lange, K. (1996).
Descent graphs in pedigree analysis: applications to haplotyping, location scores, and marker-sharing statistics.
Am J Hum Genet, 58(6):1323-37.

Speckman et al., 2003

Speckman, R. A., Wright Daw, J. A., Helms, C., Duan, S., Cao, L., Taillon-Miller, P., Kwok, P. Y., Menter, A., and Bowcock, A. M. (2003).
Novel immunoglobulin superfamily gene cluster, mapping to a region of human chromosome 17q25, linked to psoriasis susceptibility.
Hum Genet, 112(1):34-41.

Spielman et al., 1993

Spielman, R. S., McGinnis, R. E., and Ewens, W. J. (1993).
Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (iddm).
Am J Hum Genet, 52(3):506-16.

Stegmeier et al., 2007

Stegmeier, F., Sowa, M. E., Nalepa, G., Gygi, S. P., Harper, J. W., and Elledge, S. J. (2007).
The tumor suppressor cyld regulates entry into mitosis.
Proc Natl Acad Sci U S A, 104(21):8869-74.

Stemmler et al., 2007

Stemmler, S., Parwez, Q., Petrasch-Parwez, E., Epplen, J. T., and Hoffjan, S. (2007).
Two common loss-of-function mutations within the filaggrin gene predispose for early onset of atopic dermatitis.
J Invest Dermatol, 127(3):722-4.

Stevenson and Zaki, 2002

Stevenson, O. and Zaki, I. (2002).
Introduction to psoriasis.
Hospital Pharmacist, 9:187-90.

Stram, 2004

Stram, D. O. (2004).
Tag snp selection for association studies.
Genet Epidemiol, 27(4):365-74.

Stuart et al., 2005

Stuart, P., Nair, R. P., Abecasis, G. R., Nistor, I., Hiremagalore, R., Chia, N. V., Qin, Z. S., Thompson, R. A., Jenisch, S., Weichenthal, M., Janiga, J., Lim, H. W., Christophers, E., Voorhees, J. J., and Elder, J. T. (2005).
Analysis of runx1 binding site and raptor polymorphisms in psoriasis: No evidence for association despite adequate power and evidence for linkage.
J Med Genet.

Sugimura et al., 2003

Sugimura, K., Taylor, K. D., Lin, Y. C., Hang, T., Wang, D., Tang, Y. M., Fischel-Ghodsian, N., Targan, S. R., Rotter, J. I., and Yang, H. (2003).
A novel nod2/card15 haplotype conferring risk for crohn disease in ashkenazi jews.
Am J Hum Genet, 72(3):509-18.

Sugiyama et al., 2005

Sugiyama, H., Gyulai, R., Toichi, E., Garaczi, E., Shimada, S., Stevens, S. R., McCormick, T. S., and Cooper, K. D. (2005).
Dysfunctional blood and target tissue cd4+cd25high regulatory t cells in psoriasis: mechanism underlying unrestrained pathogenic effector t cell proliferation.
J Immunol, 174(1):164-73.

Sun et al., 2007

Sun, L. D., Li, W., Yang, S., Fan, X., Yan, K. L., Liang, Y. H., Gao, M., Cui, Y., Xiao, F. L., Du, W. H., Zhang, K. Y., Huang, W., Liu, J. J., and Zhang, X. J. (2007).
Evidence for a novel psoriasis susceptibility locus at 9q33-9q34 in chinese hans.
J Invest Dermatol, 127(5):1140-4.

Sun et al., 2008

Sun, L. D., Yang, S., Liu, J. J., Ren, Y. Q., Fan, X., Xu, S. X., Zhou, L., Yang, C. J., Xiao, F. L., Gao, M., Cui, Y., Du, W. H., Huang, W., and Zhang, X. J. (2008).
Follow-up analysis of 180 chinese han families: identification of a novel locus for psoriasis at 2p22.3-11.2.
Br J Dermatol, 158(3):512-7.

Suomela et al., 2007

Suomela, S., Kainu, K., Onkamo, P., Tiala, I., Himberg, J., Koskinen, L., Snellman, E., Karvonen, S. L., Karvonen, J., Uurasmaa, T., Reunala, T., Kivikas, K., Jansen, C. T., Holopainen, P., Elomaa, O., Kere, J., and Saarialho-Kere, U. (2007).
Clinical associations of the risk alleles of hla-cw6 and cchcr1*wwcc in psoriasis.
Acta Derm Venereol, 87(2):127-34.

Swynghedauw, 2001

Swynghedauw, B. (2001).
Biologie et Génétique moléculaires: aide-mémoire, chapter 2-3.
Dunod.

Szczerkowska-Dobosz et al., 2004

Szczerkowska-Dobosz, A., Rebala, K., Szczerkowska, Z., and Witkowska-Tobola, A. (2004).
Correlation of hla-cw*06 allele frequency with some clinical features of psoriasis vulgaris in the population of northern poland.
J Appl Genet, 45(4):473-6.

Takahashi et al., 2003

Takahashi, M., Matsuda, F., Margetic, N., and Lathrop, M. (2003).
Automated identification of single nucleotide polymorphisms from sequencing data.
J Bioinform Comput Biol, 1(2):253-65.

Takahashi et al., 2005

Takahashi, N., Akahoshi, M., Matsuda, A., Ebe, K., Inomata, N., Obara, K., Hirota, T., Nakashima, K., Shimizu, M., Tamari, M., Doi, S., Miyatake, A., Enomoto, T., Nakashima, H., Ikezawa, Z., and Shirakawa, T. (2005).
Association of the il12rb1 promoter polymorphisms with increased risk of atopic dermatitis and other allergic phenotypes.
Hum Mol Genet, 14(21):3149-59.

Takahashi et al., 2004

Takahashi, T., Tanaka, H., Iguchi, N., Kitamura, K., Chen, Y., Maekawa, M., Nishimura, H., Ohta, H., Miyagawa, Y., Matsumiya, K., Okuyama, A., and Nishimune, Y. (2004).
Rosbin: a novel homeobox-like protein gene expressed exclusively in round spermatids.
Biol Reprod, 70(5):1485-92.

Tarlow et al., 1997

Tarlow, J. K., Cork, M. J., Clay, F. E., Schmitt-Egenolf, M., Crane, A. M., Stierle, C., Boehncke, W. H., Eiermann, T. H., Blakemore, A. I., Bleehen, S. S., Sterry, W., and Duff, G. V. (1997).
Association between interleukin-1 receptor antagonist (il-1ra) gene polymorphism and early and late-onset psoriasis.
Br J Dermatol, 136(1):147-8.

Tazi Ahnini et al., 1999

Tazi Ahnini, R., Camp, N. J., Cork, M. J., Mee, J. B., Keohane, S. G., Duff, G. W., and di Giovine, F. S. (1999).
Novel genetic association between the corneodesmosin (mhc s) gene and susceptibility to psoriasis.
Hum Mol Genet, 8(6):1135-40.

Tazi-Ahnini et al., 1999

Tazi-Ahnini, R., di Giovine, F. S., Cox, A., Keohane, S. G., and Cork, M. J. (1999).
Corneodesmosin (mhc s) gene in guttate psoriasis.
Lancet, 354(9178):597.

Thivolet and Nicolas, 1997a

Thivolet, J. and Nicolas, J. (1997a).
Psoriasis de la clinique à la thérapeutique, chapter 41-51, pages 175-218.
John Libbey Eurotext.

Thivolet and Nicolas, 1997b

Thivolet, J. and Nicolas, J. (1997b).
Psoriasis de la clinique à la thérapeutique, chapter 5-21, pages 35-101.
John Libbey Eurotext.

Tiilikainen et al., 1980

Tiilikainen, A., Lassus, A., Karvonen, J., Vartiainen, P., and Julin, M. (1980).
Psoriasis and hla-cw6.
Br J Dermatol, 102(2):179-84.

Tokuhiro et al., 2003

Tokuhiro, S., Yamada, R., Chang, X., Suzuki, A., Kochi, Y., Sawada, T., Suzuki, M., Nagasaki, M., Ohtsuki, M., Ono, M., Furukawa, H., Nagashima, M., Yoshino, S., Mabuchi, A., Sekine, A., Saito, S., Takahashi, A., Tsunoda, T., Nakamura, Y., and Yamamoto, K. (2003).
An intronic snp in a runx1 binding site of slc22a4, encoding an organic cation transporter, is associated with rheumatoid arthritis.
Nat Genet, 35(4):341-8.

Tomfohrde et al., 1994

Tomfohrde, J., Silverman, A., Barnes, R., Fernandez-Vina, M. A., Young, M., Lory, D., Morris, L., Wuepper, K. D., Stastny, P., Menter, A., and et al. (1994).
Gene for familial psoriasis susceptibility mapped to the distal end of human chromosome 17q.
Science, 264(5162):1141-5.

Torti and Feldman, 2007

Torti, D. C. and Feldman, S. R. (2007).
Interleukin-12, interleukin-23, and psoriasis: current prospects.
J Am Acad Dermatol, 57(6):1059-68.

Trembath et al., 1997

Trembath, R. C., Clough, R. L., Rosbotham, J. L., Jones, A. B., Camp, R. D., Frodsham, A., Browne, J., Barber, R., Terwilliger, J., Lathrop, G. M., and Barker, J. N. (1997).
Identification of a major susceptibility locus on chromosome 6p and evidence for further disease loci revealed by a two stage genome-wide search in psoriasis.
Hum Mol Genet, 6(5):813-20.

Trompouki et al., 2003

Trompouki, E., Hatzivassiliou, E., Tsichritzis, T., Farmer, H., Ashworth, A., and Mosialos, G. (2003).
Cyld is a deubiquitinating enzyme that negatively regulates nf-kappab activation by tnfr family members.
Nature, 424(6950):793-6.

Tsunemi et al., 2002

Tsunemi, Y., Saeki, H., Nakamura, K., Sekiya, T., Hirai, K., Fujita, H., Asano, N., Kishimoto, M., Tanida, Y., Kakinuma, T., Mitsui, H., Tada, Y., Wakugawa, M., Torii, H., Komine, M., Asahina, A., and Tamaki, K. (2002).
Interleukin-12 p40 gene (il12b) 3'-untranslated region polymorphism is associated with susceptibility to atopic dermatitis and psoriasis vulgaris.
J Dermatol Sci, 30(2):161-6.

Tu et al., 2000

Tu, I. P., Balise, R. R., and Whittemore, A. S. (2000).
Detection of disease genes by use of family data. ii. application to nuclear families.
Am J Hum Genet, 66(4):1341-50.

Valdimarsson et al., 1997

Valdimarsson, H., Sigmundsdottir, H., and Jonsdottir, I. (1997).
Is psoriasis induced by streptococcal superantigens and maintained by m-protein-specific t cells that cross-react with keratin?
Clin Exp Immunol, 107 Suppl 1:21-4.

Van Eerdewegh et al., 2002

Van Eerdewegh, P., Little, R. D., Dupuis, J., Del Mastro, R. G., Falls, K., Simon, J., Torrey, D., Pandit, S., McKenny, J., Braunschweiger, K., Walsh, A., Liu, Z., Hayward, B., Folz, C., Manning, S. P., Bawa, A., Saracino, L., Thackston, M., Benchekroun, Y., Capparell, N., Wang, M., Adair, R., Feng, Y., Dubois, J., FitzGerald, M. G., Huang, H., Gibson, R., Allen, K. M., Pedan, A., Danzig, M. R., Umland, S. P., Egan, R. W., Cuss, F. M., Rorke, S., Clough, J. B., Holloway, J. W., Holgate, S. T., and Keith, T. P. (2002).
Association of the adam33 gene with asthma and bronchial hyperresponsiveness.
Nature, 418(6896):426-30.

Veal et al., 2002

Veal, C. D., Capon, F., Allen, M. H., Heath, E. K., Evans, J. C., Jones, A., Patel, S., Burden, D., Tillman, D., Barker, J. N., and Trembath, R. C. (2002).
Family-based analysis using a dense single-nucleotide polymorphism-based map defines genetic variation at psors1, the major psoriasis-susceptibility locus.
Am J Hum Genet, 71(3):554-64.

Veal et al., 2001

Veal, C. D., Clough, R. L., Barber, R. C., Mason, S., Tillman, D., Ferry, B., Jones, A. B., Ameen, M., Balendran, N., Powis, S. H., Burden, A. D., Barker, J. N., and Trembath, R. C. (2001).
Identification of a novel psoriasis susceptibility locus at 1p and evidence of epistasis between psors1 and candidate loci.
J Med Genet, 38(1):7-13.

Velaga et al., 2004

Velaga, M. R., Wilson, V., Jennings, C. E., Owen, C. J., Herington, S., Donaldson, P. T., Ball, S. G., James, R. A., Quinton, R., Perros, P., and Pearce, S. H. (2004).
The codon 620 tryptophan allele of the lymphoid tyrosine phosphatase (lyp) gene is a major determinant of graves' disease.
J Clin Endocrinol Metab, 89(11):5862-5.

Vereecken et al., 2007

Vereecken, P., Provost, P., Willaert, F., Heenen, M., and Bentin, J. (2007).
[the treatment of psoriasis: basic principles and new options].
Rev Med Brux, 28(4):336-44.

Walsh et al., 2003

Walsh, E. C., Mather, K. A., Schaffner, S. F., Farwell, L., Daly, M. J., Patterson, N., Cullen, M., Carrington, M., Bugawan, T. L., Erlich, H., Campbell, J., Barrett, J., Miller, K., Thomson, G., Lander, E. S., and Rioux, J. D. (2003).
An integrated haplotype map of the human major histocompatibility complex.
Am J Hum Genet, 73(3):580-90.

Watanabe et al., 2004

Watanabe, T., Kitani, A., Murray, P. J., and Strober, W. (2004).
Nod2 is a negative regulator of toll-like receptor 2-mediated t helper type 1 responses.
Nat Immunol, 5(8):800-8.

Watford et al., 2003

Watford, W. T., Moriguchi, M., Morinobu, A., and O'Shea, J. J. (2003).
The biology of il-12: coordinating innate and adaptive immune responses.
Cytokine Growth Factor Rev, 14(5):361-8.

Weeks and Lange, 1988

Weeks, D. E. and Lange, K. (1988).
The affected-pedigree-member method of linkage analysis.
Am J Hum Genet, 42(2):315-26.

Weeks et al., 1990

Weeks, D. E., Lehner, T., Squires-Wheeler, E., Kaufmann, C., and Ott, J. (1990).
Measuring the inflation of the lod score due to its maximization over model parameter values in human linkage analysis.
Genet Epidemiol, 7(4):237-43.

Weichenthal et al., 2007

Weichenthal, M., Ruether, A., Schreiber, S., Nair, R., Voorhees, J. J., Schwarz, T., Kabelitz, D., Christophers, E., Elder, J. T., and Jenisch, S. (2007).
Filaggrin r501x and 2282del4 mutations are not associated with chronic plaque-type psoriasis in a german cohort.
J Invest Dermatol, 127(6):1535-7.

Weidinger et al., 2006

Weidinger, S., Illig, T., Baurecht, H., Irvine, A. D., Rodriguez, E., Diaz-Lacava, A., Klopp, N., Wagenpfeil, S., Zhao, Y., Liao, H., Lee, S. P., Palmer, C. N., Jenneck, C., Maintz, L., Hagemann, T., Behrendt, H., Ring, J., Nothen, M. M., McLean, W. H., and Novak, N. (2006).
Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations.
J Allergy Clin Immunol, 118(1):214-9.

Weidinger et al., 2005

Weidinger, S., Klopp, N., Rummler, L., Wagenpfeil, S., Baurecht, H. J., Gauger, A., Darsow, U., Jakob, T., Novak, N., Schafer, T., Heinrich, J., Behrendt, H., Wichmann, H. E., Ring, J., and Illig, T. (2005).
Association of card15 polymorphisms with atopy-related traits in a population-based cohort of caucasian adults.
Clin Exp Allergy, 35(7):866-72.

Wigginton and Abecasis, 2005

Wigginton, J. E. and Abecasis, G. R. (2005).
Pedstats: descriptive statistics, graphics and quality assessment for gene mapping data.
Bioinformatics, 21(16):3445-7.

Wolf et al., 2008

Wolf, N., Quaranta, M., Prescott, N. J., Allen, M., Smith, R., Burden, A. D., Worthington, J., Griffiths, C. E., Mathew, C. G., Barker, J. N., Capon, F., and Trembath, R. C. (2008).
Psoriasis is associated with pleiotropic susceptibility loci identified in type ii diabetes and crohn disease.
J Med Genet, 45(2):114-6.

Wooster et al., 1995

Wooster, R., Bignell, G., Lancaster, J., Swift, S., Seal, S., Mangion, J., Collins, N., Gregory, S., Gumbs, C., and Micklem, G. (1995).
Identification of the breast cancer susceptibility gene brca2.
Nature, 378(6559):789-92.

Wrone-Smith and Nickoloff, 1996

Wrone-Smith, T. and Nickoloff, B. J. (1996).
Dermal injection of immunocytes induces psoriasis.
J Clin Invest, 98(8):1878-87.

Wu et al., 1997

Wu, C., Ferrante, J., Gately, M. K., and Magram, J. (1997).
Characterization of il-12 receptor beta1 chain (il-12rbeta1)-deficient mice: Il-12rbeta1 is an essential component of the functional mouse il-12 receptor.
J Immunol, 159(4):1658-65.

Wu et al., 2000

Wu, C., Wang, X., Gadina, M., O'Shea, J. J., Presky, D. H., and Magram, J. (2000).
Il-12 receptor beta 2 (il-12r beta 2)-deficient mice are defective in il-12-mediated signaling despite the presence of high affinity il-12 binding sites.
J Immunol, 165(11):6221-8.

Wu and Gu, 2007

Wu, Z. and Gu, J. R. (2007).
[a meta-analysis on interleukin-1 gene cluster polymorphism and genetic susceptibility for ankylosing spondylitis].
Zhonghua Yi Xue Za Zhi, 87(7):433-7.

Xu and Shete, 2007

Xu, H. and Shete, S. (2007).
Mixed-effects logistic approach for association following linkage scan for complex disorders.
Ann Hum Genet, 71(Pt 2):230-7.

Yamada and Ymamoto, 2005

Yamada, R. and Ymamoto, K. (2005).
Recent findings on genes associated with inflammatory disease.
Mutat Res, 573(1-2):136-51.

Yan et al., 2007

Yan, K. L., Huang, W., Zhang, X. J., Yang, S., Chen, Y. M., Xiao, F. L., Fan, X., Gao, M., Cui, Y., Zhang, G. L., Sun, L. D., Wang, P. G., Chen, J. J., Li, W., Chen, Z. H., Wang, Z. M., Wang, D. Z., Zhang, K. Y., and Liu, J. J. (2007).
Follow-up analysis of psors9 in 151 chinese families confirmed the linkage to 4q31-32 and refined the evidence to the families of early-onset psoriasis.
J Invest Dermatol, 127(2):312-8.

Yang et al., 2008

Yang, C. F., Hwu, W. L., Yang, L. C., Chung, W. H., Chien, Y. H., Hung, C. F., Chen, H. C., Tsai, P. J., Fann, C. S., Liao, F., and Chen, Y. T. (2008).
A promoter sequence variant of znf750 is linked with familial psoriasis.
J Invest Dermatol, 128(7):1662-8.

Yoshinaka et al., 2002

Yoshinaka, T., Nishii, K., Yamada, K., Sawada, H., Nishiwaki, E., Smith, K., Yoshino, K., Ishiguro, H., and Higashiyama, S. (2002).
Identification and characterization of novel mouse and human adam33s with potential metalloprotease activity.
Gene, 282(1-2):227-36.

Young et al., 2003

Young, C., Allen, M. H., Cuthbert, A., Ameen, M., Veal, C., Leman, J., Burden, A. D., Kirby, B., Griffiths, C. E., Trembath, R. C., Mathew, C. G., and Barker, J. N. (2003).
A crohn's disease-associated insertion polymorphism (3020insc) in the nod2 gene is not associated with psoriasis vulgaris, palmo-plantar pustular psoriasis or guttate psoriasis.
Exp Dermatol, 12(4):506-9.

Zenz et al., 2005

Zenz, R., Eferl, R., Kenner, L., Florin, L., Hummerich, L., Mehic, D., Scheuch, H., Angel, P., Tschachler, E., and Wagner, E. F. (2005).
Psoriasis-like skin disease and arthritis caused by inducible epidermal deletion of jun proteins.
Nature, 437(7057):369-75.

Zenz and Wagner, 2006

Zenz, R. and Wagner, E. F. (2006).
Jun signalling in the epidermis: From developmental defects to psoriasis and skin tumors.
Int J Biochem Cell Biol, 38(7):1043-9.

Zhang et al., 2002

Zhang, X. J., He, P. P., Wang, Z. X., Zhang, J., Li, Y. B., Wang, H. Y., Wei, S. C., Chen, S. Y., Xu, S. J., Jin, L., Yang, S., and Huang, W. (2002).
Evidence for a major psoriasis susceptibility locus at 6p21(psors1) and a novel candidate region at 4q31 by genome-wide scan in chinese hans.
J Invest Dermatol, 119(6):1361-6.

Zhao et al., 2007

Zhao, Y., Terron-Kwiatkowski, A., Liao, H., Lee, S. P., Allen, M. H., Hull, P. R., Campbell, L. E., Trembath, R. C., Capon, F., Griffiths, C. E., Burden, D., McManus, R., Hughes, R., Kirby, B., Rogers, S. F., Fitzgerald, O., Kane, D., Barker, J. N., Palmer, C. N., Irvine, A. D., and McLean, W. H. (2007).
Filaggrin null alleles are not associated with psoriasis.
J Invest Dermatol, 127(8):1878-82.

Zheng et al., 2003

Zheng, J., Jin, S., and Shi, R. (2003).
Confirmation of psors psoriasis susceptibility loci in a chinese population.
Arch Dermatol Res, 295(1):14-8.

Zhou et al., 2003

Zhou, X., Krueger, J. G., Kao, M. C., Lee, E., Du, F., Menter, A., Wong, W. H., and Bowcock, A. M. (2003).
Novel mechanisms of t-cell and dendritic cell activation revealed by profiling of psoriasis on the 63,100-element oligonucleotide array.
Physiol Genomics, 13(1):69-78.

Zhou and Chaplin, 1993

Zhou, Y. and Chaplin, D. D. (1993).
Identification in the hla class i region of a gene expressed late in keratinocyte differentiation.
Proc Natl Acad Sci U S A, 90(20):9470-4.